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THE EFFECT OF EFFERENT, PARASYMPATHETIC STIMULATION UPON PANCREATIC POLYPEPTIDE (PP) SECRETION WAS STUDIED IN THREE WAYS: (a) Plasma PP concentrations increased in response to insulin-induced hypoglycemia in both normal subjects, from 11 pM (9.5-12.5) to 136 pM (118-147), n = 8 (median and interquartile range) and in duodenal ulcer patients, from 33 pM (21-52) to 213 pM (157-233), n = 7. The PP response to hypoglycemia was diminished by atropine in normal subjects (P < 0.005) and completely abolished by vagotomy in the duodenal ulcer patients. (b) Electrical stimulation, 8 Hz, of the vagal nerves in anesthetized pigs induced an increase in portal PP concentrations within 30 s from 32 pM (28-39) to 285 pM (248-294), n = 12. Minimal stimulatory frequency was 0.5 Hz and maximal stimulatory frequency 8-12 Hz. Atropine inhibited the PP response to electrical stimulation. Median inhibition with 0.5 mg of atropine/kg body wt was 74%, range 31-90%, n = 6. The response was eliminated by hexamethonium. Adrenergic alpha and beta blockade did not influence the release of PP in response to vagal stimulation. (c) Acetylcholine stimulated, in a dose-dependent manner, the secretion of PP from the isolated perfused porcine pancreas, half-maximal effective dose being 0.19 muM; maximal PP output in response to 5 min stimulation was 228 pmol, range 140-342 pmol, n = 5. Atropine completely abolished this response.The results of the present study together with the previously demonstrated poor PP response to food in vagotomized patients, indicate that vagal, cholinergic stimulation is a major regulator of PP secretion.
T W Schwartz, and
J J Holst, and
J Fahrenkrug, and
S L Jensen, and
O V Nielsen, and
J F Rehfeld, and
O B de Muckadell, and
F Stadil
July 1984,
Clinical endocrinology,
T W Schwartz, and
J J Holst, and
J Fahrenkrug, and
S L Jensen, and
O V Nielsen, and
J F Rehfeld, and
O B de Muckadell, and
F Stadil
August 1997,
The Journal of endocrinology,
T W Schwartz, and
J J Holst, and
J Fahrenkrug, and
S L Jensen, and
O V Nielsen, and
J F Rehfeld, and
O B de Muckadell, and
F Stadil
November 1987,
The American journal of physiology,
T W Schwartz, and
J J Holst, and
J Fahrenkrug, and
S L Jensen, and
O V Nielsen, and
J F Rehfeld, and
O B de Muckadell, and
F Stadil
August 1981,
Hepato-gastroenterology,
T W Schwartz, and
J J Holst, and
J Fahrenkrug, and
S L Jensen, and
O V Nielsen, and
J F Rehfeld, and
O B de Muckadell, and
F Stadil
April 1982,
Gastroenterologie clinique et biologique,
T W Schwartz, and
J J Holst, and
J Fahrenkrug, and
S L Jensen, and
O V Nielsen, and
J F Rehfeld, and
O B de Muckadell, and
F Stadil
November 1995,
The American journal of physiology,
T W Schwartz, and
J J Holst, and
J Fahrenkrug, and
S L Jensen, and
O V Nielsen, and
J F Rehfeld, and
O B de Muckadell, and
F Stadil
October 1997,
Regulatory peptides,
T W Schwartz, and
J J Holst, and
J Fahrenkrug, and
S L Jensen, and
O V Nielsen, and
J F Rehfeld, and
O B de Muckadell, and
F Stadil
April 1983,
The American journal of physiology,
T W Schwartz, and
J J Holst, and
J Fahrenkrug, and
S L Jensen, and
O V Nielsen, and
J F Rehfeld, and
O B de Muckadell, and
F Stadil
January 1993,
The American journal of physiology,
T W Schwartz, and
J J Holst, and
J Fahrenkrug, and
S L Jensen, and
O V Nielsen, and
J F Rehfeld, and
O B de Muckadell, and
F Stadil
March 1993,
Pancreas,
