Biomaterial Database

Different effect of diatrizoate and iopamidol on prostaglandin synthesis in perfused hamster lungs. 1983

H Paajanen, and P Uotila, and M Kormano

The synthesis of prostaglandins and other metabolic products of arachidonic acid (AA) was investigated in isolated perfused lungs of hamsters during the infusion of various concentrations of meglumine diatrizoate and iopamidol. Forty nmol of 14C-AA was infused into the pulmonary circulation with radiographic contrast media (RCM), and prostaglandins, thromboxanes, and metabolites of lipoxygenases were analyzed from the nonrecirculating perfusion effluent. Arachidonate infusion increased the perfusion pressure. This pressor response was decreased by iopamidol but was not changed by diatrizoate. The amount of radioactivity was decreased in the perfusion effluent and increased in lung lipids by iopamidol. Meglumine diatrizoate increased radioactivity in the effluent with minimal effects on the distribution of radioactivity in lung lipids. Almost all arachidonate metabolites were decreased significantly by iopamidol when compared with hypertonic saline whereas diatrizoate caused an increasing trend in the formation of the metabolites of AA. The present study shows that ionic and nonionic RCM have different effects on the metabolism of arachidonic acid.

UI	MeSH Term	Description	Entries
D007479	Iopamidol	A non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiological procedures.	B-15,000,B-15000,Gastromiro,Iopamidol, (+-)-Isomer,Iopamidol, (R)-Isomer,Iopamidol, Sodium Salt, (S)-Isomer,Iopamiro,Isovue,Isovue 370,Jopamidol,Niopam,SQ 13,396,Solutrast,Solutrast 370,Solutrast Gastro,B 15,000,B 15000,B15,000,B15000
D007483	Iothalamic Acid	A contrast medium in diagnostic radiology with properties similar to those of diatrizoic acid. It is used primarily as its sodium and meglumine (IOTHALAMATE MEGLUMINE) salts.	Iotalamic Acid,Methalamic Acid,Angio-Conray,Conray 420,Iodothalamate,Iothalamate,Iothalamic Acid, Calcium (2:1) Salt,Iothalamic Acid, Monosilver (1+) Salt,Iothalamic Acid, Monosodium Salt,Iothalamic Acid, Monosodium Salt, Dimer,Lopamidol,Sodium Iothalamate,Acid, Iotalamic,Acid, Iothalamic,Acid, Methalamic,Angio Conray,AngioConray,Iothalamate, Sodium
D008168	Lung	Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.	Lungs
D008647	Mesocricetus	A genus in the order Rodentia and family Cricetidae. One species, Mesocricetus auratus or golden hamster is widely used in biomedical research.	Hamsters, Golden,Hamsters, Golden Syrian,Hamsters, Syrian,Mesocricetus auratus,Syrian Golden Hamster,Syrian Hamster,Golden Hamster,Golden Hamster, Syrian,Golden Hamsters,Golden Syrian Hamsters,Hamster, Golden,Hamster, Syrian,Hamster, Syrian Golden,Syrian Hamsters
D011453	Prostaglandins	A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.	Prostaglandin,Prostanoid,Prostanoids
D003287	Contrast Media	Substances used to allow enhanced visualization of tissues.	Radiopaque Media,Contrast Agent,Contrast Agents,Contrast Material,Contrast Materials,Radiocontrast Agent,Radiocontrast Agents,Radiocontrast Media,Agent, Contrast,Agent, Radiocontrast,Agents, Contrast,Agents, Radiocontrast,Material, Contrast,Materials, Contrast,Media, Contrast,Media, Radiocontrast,Media, Radiopaque
D003973	Diatrizoate	A commonly used x-ray contrast medium. As DIATRIZOATE MEGLUMINE and as Diatrizoate sodium, it is used for gastrointestinal studies, angiography, and urography.	Amidotrezoate,Amidotrizoate,Benzoic acid, 3,5-bis(acetylamino)-2,4,6-triiodo-,Diatrizoate Sodium,Diatrizoic Acid,Hypaque,Hypaque 50,Sodium Diatrizoate,Sodium-Magnesium Diatrizoate,Urogranoic Acid,Urothrast,Urotrast,Diatrizoate, Sodium,Diatrizoate, Sodium-Magnesium
D003974	Diatrizoate Meglumine	A versatile contrast medium used for DIAGNOSTIC X-RAY RADIOLOGY.	Diatrizoate Methylglucamine,Diatrizoic Acid Methylglucamine,Meglumine Diatrizoate,Methylglucamine Diatrizoate,Amidotricoic Acid,Amidotrizoic Acid,Angiografin,Gastrograffin,Gastrografin,Gastrographin,Ioxeol,Meglumine Amidotrizoate,Reno 60,Reno M-Dip,Renograffin,Renografin,Renografin M-76,Sinografin,Triombrast,Triombrin,Urografin,Urografin 76,Urovist,Verografin,Amidotrizoate, Meglumine,Diatrizoate, Meglumine,Diatrizoate, Methylglucamine,Meglumine, Diatrizoate,Methylglucamine, Diatrizoate,Methylglucamine, Diatrizoic Acid,Reno M Dip,Reno MDip,Renografin M 76,Renografin M76
D005260	Female		Females
D006224	Cricetinae	A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.	Cricetus,Hamsters,Hamster