Relative hemostatic effectiveness of human platelets stored at 4 degrees and 22 degrees C. 1978

D J Filip, and R H Aster

Platelet concentrates stored at 2 degrees to 4 degrees C or at 20 degrees to 24 degrees C for 24 or 72 hr were transfused to 22 thrombocytopenic patients selected to minimize host factors which affect the survival and function of transfused platelets. Platelets stored at either temperature range for only 24 hr were equally effective in elevating platelet levels and in shortening bleeding times, 1, 4 and 24 hr after transfusion. After 72 hr of storage, however, refrigerated platelets were significantly less effective than platelets kept at room temperature by these two criteria. We suggest that routine storage of platelets at 2 degrees to 4 degrees C can no longer be justified except possibly when platelets are to be shipped over long distance by common carrier and transfused within 24 hr of preparation.

UI MeSH Term Description Entries
D001780 Blood Coagulation Tests Laboratory tests for evaluating the individual's clotting mechanism. Coagulation Tests, Blood,Tests, Blood Coagulation,Blood Coagulation Test,Coagulation Test, Blood,Test, Blood Coagulation
D001792 Blood Platelets Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation. Platelets,Thrombocytes,Blood Platelet,Platelet,Platelet, Blood,Platelets, Blood,Thrombocyte
D001793 Blood Preservation The process by which blood or its components are kept viable outside of the organism from which they are derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism). Blood Preservations,Preservation, Blood,Preservations, Blood
D001803 Blood Transfusion The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed) Blood Transfusions,Transfusion, Blood,Transfusions, Blood
D002470 Cell Survival The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability. Cell Viability,Cell Viabilities,Survival, Cell,Viabilities, Cell,Viability, Cell
D003080 Cold Temperature An absence of warmth or heat or a temperature notably below an accustomed norm. Cold,Cold Temperatures,Temperature, Cold,Temperatures, Cold
D006487 Hemostasis The process which spontaneously arrests the flow of BLOOD from vessels carrying blood under pressure. It is accomplished by contraction of the vessels, adhesion and aggregation of formed blood elements (eg. ERYTHROCYTE AGGREGATION), and the process of BLOOD COAGULATION. Hemostases
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013696 Temperature The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms. Temperatures
D013921 Thrombocytopenia A subnormal level of BLOOD PLATELETS. Thrombopenia,Thrombocytopenias,Thrombopenias

Related Publications

D J Filip, and R H Aster
September 1971, The New England journal of medicine,
D J Filip, and R H Aster
May 2014, Shock (Augusta, Ga.),
D J Filip, and R H Aster
October 1986, The Tohoku journal of experimental medicine,
D J Filip, and R H Aster
January 1976, Acta haematologica,
D J Filip, and R H Aster
January 1981, Vox sanguinis,
D J Filip, and R H Aster
June 1982, Thrombosis and haemostasis,
Copied contents to your clipboard!