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N-Acetyl-beta-D-glucosaminidase (NAG), beta-D-galactosidase, alkaline phosphatase (ALP) and leucine aminopeptidase (LAP) were assayed in the urine of 100 normal and 112 hypertensive subjects. Age-related urinary activities for these enzymes in the normotensive control subjects are presented. A new procedure for the assay of urinary ALP using 2-methoxy-4-(2'-nitrovinyl)phenyl (MNP) phosphate is described. Thirty-five of the hypertensive patients were considered to have primary renal disease. The urinary activity of NAG was increased in 27 (77%) of these patients and the detection of primary renal disease was not enhanced by measurements of the other urinary enzymes. Testing the urine both for NAG activity and protein, led to the detection of 91% of these patients. The assay procedures described are simple to perform and can be carried out in outpatient clinics. The measurement of urinary NAG activity is a cheap and reliable method for detecting renal disease in hypertensive patients but maximum diagnostic yield is achieved when proteinuria is determined as well.
I D Johnston, and
N F Jones, and
J E Scoble, and
C T Yuen, and
R G Price
January 1966,
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I D Johnston, and
N F Jones, and
J E Scoble, and
C T Yuen, and
R G Price
June 1977,
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I D Johnston, and
N F Jones, and
J E Scoble, and
C T Yuen, and
R G Price
January 1972,
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I D Johnston, and
N F Jones, and
J E Scoble, and
C T Yuen, and
R G Price
March 1971,
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I D Johnston, and
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J E Scoble, and
C T Yuen, and
R G Price
January 1996,
Transplant international : official journal of the European Society for Organ Transplantation,
I D Johnston, and
N F Jones, and
J E Scoble, and
C T Yuen, and
R G Price
February 1978,
Zeitschrift fur medizinische Laboratoriumsdiagnostik,
I D Johnston, and
N F Jones, and
J E Scoble, and
C T Yuen, and
R G Price
January 1965,
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I D Johnston, and
N F Jones, and
J E Scoble, and
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R G Price
January 2016,
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I D Johnston, and
N F Jones, and
J E Scoble, and
C T Yuen, and
R G Price
December 1990,
JAMA,
I D Johnston, and
N F Jones, and
J E Scoble, and
C T Yuen, and
R G Price
January 2021,
Wiadomosci lekarskie (Warsaw, Poland : 1960),
