-transparent.png){kind=logo}
To assess the immunologic status of healthy persons with hemophilia A, we performed studies of T cell immunity in 21 patients, 10 given only cryoprecipitate and 11 given factor VIII concentrate. Patients in the factor VIII group had significantly decreased helper/suppressor T cell ratios. Both groups had diminished mononuclear cell response to phytohemagglutinin and normal mixed lymphocyte culture, compared with controls. Abnormalities in T cell number or function did not correlate with the presence of antibody to cytomegalovirus, Epstein-Barr virus, or hepatitis B. Physicians caring for patients with hemophilia A should realize that asymptomatic individuals may have early evidence of immunodeficiency.
P S Weintrub, and
M A Koerper, and
J E Addiego, and
W L Drew, and
E T Lennette, and
R Miner, and
M J Cowan, and
A J Ammann
April 1986,
The Journal of pediatrics,
P S Weintrub, and
M A Koerper, and
J E Addiego, and
W L Drew, and
E T Lennette, and
R Miner, and
M J Cowan, and
A J Ammann
October 1988,
European journal of haematology,
P S Weintrub, and
M A Koerper, and
J E Addiego, and
W L Drew, and
E T Lennette, and
R Miner, and
M J Cowan, and
A J Ammann
April 1984,
Canadian Medical Association journal,
P S Weintrub, and
M A Koerper, and
J E Addiego, and
W L Drew, and
E T Lennette, and
R Miner, and
M J Cowan, and
A J Ammann
May 1988,
Pediatria polska,
P S Weintrub, and
M A Koerper, and
J E Addiego, and
W L Drew, and
E T Lennette, and
R Miner, and
M J Cowan, and
A J Ammann
January 1988,
Bollettino dell'Istituto sieroterapico milanese,
P S Weintrub, and
M A Koerper, and
J E Addiego, and
W L Drew, and
E T Lennette, and
R Miner, and
M J Cowan, and
A J Ammann
May 1977,
Journal of the National Cancer Institute,
P S Weintrub, and
M A Koerper, and
J E Addiego, and
W L Drew, and
E T Lennette, and
R Miner, and
M J Cowan, and
A J Ammann
August 1982,
American journal of clinical pathology,
P S Weintrub, and
M A Koerper, and
J E Addiego, and
W L Drew, and
E T Lennette, and
R Miner, and
M J Cowan, and
A J Ammann
March 1983,
Annals of internal medicine,
P S Weintrub, and
M A Koerper, and
J E Addiego, and
W L Drew, and
E T Lennette, and
R Miner, and
M J Cowan, and
A J Ammann
May 1983,
American journal of hematology,
P S Weintrub, and
M A Koerper, and
J E Addiego, and
W L Drew, and
E T Lennette, and
R Miner, and
M J Cowan, and
A J Ammann
July 1987,
Blood,
