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The in vitro antitumor activity of 7-N-(p-hydroxyphenyl)-mitomycin C (KW-2083) against cultured bronchogenic carcinoma cells (PC-7) was compared with that of mitomycin C, using a 3H-thymidine uptake assay. The uptake of 3H-thymidine into PC-7 cells was well correlated with the cell concentration under 1 X 10(5)/ml. It was more strongly inhibited after incubation of the PC-7 cells with KW-2083 than with mitomycin C at the concentration of 0.5, 2.5 and 10 micrograms/ml for 20 and 60 min. The placebo of KW-2083 containing HCO-60 and propyleneglycol showed no effect on the uptake of 3H-thymidine by PC-7 cells.
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