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The graft of a transplantable leukemia (IW 32) induced by a biologically cloned helper of a Friend virus devoid of SFFV activity, was shown to induce a polycythemia in recipient animals. An in vitro continuous cell line was derived from this leukemia. The supernatant was shown to induce an erythroid differentiation both in vivo in Mice rendered polycythemic by transfusion, and in vitro in plasma clot CFUE assay. This erythropoietic activity was heat stable (30 min. 56 degrees C, 3 min. 100 degrees C) which ruled out the hypothesis that the IW 32 cell line produced a polycythemia inducing virus. The erythropoietic factor produced by IW 32 leukemic cells might be erythropoietin.
P Tambourin, and
F Wendling, and
P Bucau-Varlet, and
M Charon, and
O Muller, and
N Casadevall, and
C Lacombe, and
J Choppin, and
B Varet
January 1961,
Acta haematologica,
P Tambourin, and
F Wendling, and
P Bucau-Varlet, and
M Charon, and
O Muller, and
N Casadevall, and
C Lacombe, and
J Choppin, and
B Varet
December 1954,
Endocrinology,
P Tambourin, and
F Wendling, and
P Bucau-Varlet, and
M Charon, and
O Muller, and
N Casadevall, and
C Lacombe, and
J Choppin, and
B Varet
December 1963,
Bollettino della Societa italiana di biologia sperimentale,
P Tambourin, and
F Wendling, and
P Bucau-Varlet, and
M Charon, and
O Muller, and
N Casadevall, and
C Lacombe, and
J Choppin, and
B Varet
February 1978,
Experimental cell research,
P Tambourin, and
F Wendling, and
P Bucau-Varlet, and
M Charon, and
O Muller, and
N Casadevall, and
C Lacombe, and
J Choppin, and
B Varet
June 1959,
Annals of the New York Academy of Sciences,
P Tambourin, and
F Wendling, and
P Bucau-Varlet, and
M Charon, and
O Muller, and
N Casadevall, and
C Lacombe, and
J Choppin, and
B Varet
October 1956,
Blood,
P Tambourin, and
F Wendling, and
P Bucau-Varlet, and
M Charon, and
O Muller, and
N Casadevall, and
C Lacombe, and
J Choppin, and
B Varet
December 1963,
Bollettino della Societa italiana di biologia sperimentale,
P Tambourin, and
F Wendling, and
P Bucau-Varlet, and
M Charon, and
O Muller, and
N Casadevall, and
C Lacombe, and
J Choppin, and
B Varet
January 1976,
The Journal of laboratory and clinical medicine,
P Tambourin, and
F Wendling, and
P Bucau-Varlet, and
M Charon, and
O Muller, and
N Casadevall, and
C Lacombe, and
J Choppin, and
B Varet
February 1971,
Annals of clinical research,
P Tambourin, and
F Wendling, and
P Bucau-Varlet, and
M Charon, and
O Muller, and
N Casadevall, and
C Lacombe, and
J Choppin, and
B Varet
September 1984,
Biulleten' eksperimental'noi biologii i meditsiny,
