-transparent.png){kind=logo}
Phospholipase A2 activity of polymorphonuclear leukocytes (PMNLs) towards radioactively labelled phosphatidylethanolamine is inhibited by FOY (ethyl 4-(6-guanidinohexanoyloxy)-benzoate methanesulfonate) in concentrations above 10(-4)M. The inhibition is noncompetitive with respect to the substrate employed and depends on the pH. Impairment of PMNL phospholipase A2 activity could play a role in the anti-inflammatory effect of FOY: the release of fatty acids from membrane phospholipids is reduced and consequently also the biosynthesis of bioactive oxygenated arachidonate metabolites, among them inflammatory mediators.
Related Publications
H Kunze, and
E Bohn, and
B Damerau
December 1984,
Agents and actions,
H Kunze, and
E Bohn, and
B Damerau
November 1998,
The Proceedings of the Nutrition Society,
H Kunze, and
E Bohn, and
B Damerau
January 1974,
Methods in enzymology,
H Kunze, and
E Bohn, and
B Damerau
May 1980,
Biochimica et biophysica acta,
H Kunze, and
E Bohn, and
B Damerau
June 1978,
Proceedings of the National Academy of Sciences of the United States of America,
H Kunze, and
E Bohn, and
B Damerau
December 1981,
FEBS letters,
H Kunze, and
E Bohn, and
B Damerau
November 1992,
Biochemical and biophysical research communications,
H Kunze, and
E Bohn, and
B Damerau
December 1963,
The American journal of physiology,
H Kunze, and
E Bohn, and
B Damerau
July 1984,
Pharmacological research communications,
H Kunze, and
E Bohn, and
B Damerau
December 2006,
Life sciences,
