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Nephrocalcinosis was induced in a group of experimental rats by means of intraperitoneal injections of 10% calcium gluconate. Two further groups of rats were treated with indomethacin and flurbiprofen (Froben) before receiving the i.p. calcium gluconate, to study the effects of prostaglandin inhibition on the process of renal parenchymal calcification. Tissue calcification was studied by means of contact microradiography and histology. Quantitative calcium analysis was by means of energy dispersive analysis of X-rays (EDAX). There was a marked inhibition of cortical nephrocalcinosis and a significantly reduced calcium concentration (P less than 0.005) in the animals treated with a prostaglandin inhibitor compared with the animals given i.p. calcium gluconate alone. This study suggests that prostaglandins are involved in the process of renal parenchymal calcification and may be aetiologically significant in the pathogenesis of stone formation.
A C Buck, and
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B Leaker, and
D B Moffat
November 1977,
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A C Buck, and
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August 1987,
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A C Buck, and
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D B Moffat
September 1990,
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A C Buck, and
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July 1956,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
A C Buck, and
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D B Moffat
July 1984,
Lancet (London, England),
A C Buck, and
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D B Moffat
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Experientia,
A C Buck, and
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B Leaker, and
D B Moffat
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A C Buck, and
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D B Moffat
August 1982,
The Journal of pediatrics,
A C Buck, and
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A C Buck, and
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Archives of disease in childhood,
