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The purpose of this study was to evaluate the disposition kinetics of digoxin after the administration of a single intravenous dose to the same dogs before and during azotemia. The digoxin plasma concentration-time data were fitted to a multicompartment model using nonlinear regression analysis. During azotemia, the biological half-life of digoxin was prolonged in six of seven dogs, while digoxin renal clearance, body clearance and apparent volume of distribution were significantly decreased. There was a corresponding increase in the apparent volume of the "central" compartment of digoxin. Approximately 45% of a digoxin dose was excreted by the kidney in these animals indicating a substantial nonrenal component to digoxin elimination in the dog. This nonrenal elimination did not change during azotemia, despite a decrease in renal clearance by 61%.
K D Gierke, and
D Perrier, and
M Mayersohn, and
F I Marcus
December 1969,
Journal of pharmaceutical sciences,
K D Gierke, and
D Perrier, and
M Mayersohn, and
F I Marcus
September 1981,
Archives internationales de pharmacodynamie et de therapie,
K D Gierke, and
D Perrier, and
M Mayersohn, and
F I Marcus
January 1980,
Arzneimittel-Forschung,
K D Gierke, and
D Perrier, and
M Mayersohn, and
F I Marcus
October 1980,
American journal of veterinary research,
K D Gierke, and
D Perrier, and
M Mayersohn, and
F I Marcus
June 1984,
Journal of pharmaceutical sciences,
K D Gierke, and
D Perrier, and
M Mayersohn, and
F I Marcus
September 1980,
Toxicology and applied pharmacology,
K D Gierke, and
D Perrier, and
M Mayersohn, and
F I Marcus
May 1977,
Clinical pharmacology and therapeutics,
K D Gierke, and
D Perrier, and
M Mayersohn, and
F I Marcus
March 1993,
Biopharmaceutics & drug disposition,
K D Gierke, and
D Perrier, and
M Mayersohn, and
F I Marcus
July 1970,
The Journal of pharmacology and experimental therapeutics,
K D Gierke, and
D Perrier, and
M Mayersohn, and
F I Marcus
February 1987,
Journal of pharmacokinetics and biopharmaceutics,
