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The possible use of pipemidic acid for preventing infections in granulocytopenic patients by selective elimination of the gram-negative rods from the digestive tract was evaluated. Fecal samples were collected before, during, and after therapy from 23 adults who were undergoing treatment of urinary tract infections with pipemidic acid at a dosage of 200 mg orally four times daily for 10 days. The concentration of pipemidic acid in the majority of the stool samples tested was 220 to 600 micrograms/g. However, in 19% of the samples collected on day 5, the concentration was below the detection limit (23 micrograms/ml). Approximately 90% of the fecal samples collected during or shortly after therapy were negative for members of the family Enterobacteriaceae. Resistance of the gastrointestinal tract against colonization by microorganisms from the environment (so-called colonization resistance) remained unimpaired, as measured by the absence of beta-aspartylglycine in the stool.
H L Muytjens, and
G L van Veldhuizen, and
G W Welling, and
J van der Ros-van de Repe, and
H B Boerema, and
D van der Waaij
October 2010,
Enfermedades infecciosas y microbiologia clinica,
H L Muytjens, and
G L van Veldhuizen, and
G W Welling, and
J van der Ros-van de Repe, and
H B Boerema, and
D van der Waaij
November 1991,
Lancet (London, England),
H L Muytjens, and
G L van Veldhuizen, and
G W Welling, and
J van der Ros-van de Repe, and
H B Boerema, and
D van der Waaij
July 1992,
The New England journal of medicine,
H L Muytjens, and
G L van Veldhuizen, and
G W Welling, and
J van der Ros-van de Repe, and
H B Boerema, and
D van der Waaij
July 1992,
The New England journal of medicine,
H L Muytjens, and
G L van Veldhuizen, and
G W Welling, and
J van der Ros-van de Repe, and
H B Boerema, and
D van der Waaij
December 1989,
BMJ (Clinical research ed.),
H L Muytjens, and
G L van Veldhuizen, and
G W Welling, and
J van der Ros-van de Repe, and
H B Boerema, and
D van der Waaij
February 1994,
BMJ (Clinical research ed.),
H L Muytjens, and
G L van Veldhuizen, and
G W Welling, and
J van der Ros-van de Repe, and
H B Boerema, and
D van der Waaij
April 2008,
Current opinion in infectious diseases,
H L Muytjens, and
G L van Veldhuizen, and
G W Welling, and
J van der Ros-van de Repe, and
H B Boerema, and
D van der Waaij
April 2002,
Current opinion in critical care,
H L Muytjens, and
G L van Veldhuizen, and
G W Welling, and
J van der Ros-van de Repe, and
H B Boerema, and
D van der Waaij
January 1990,
BMJ (Clinical research ed.),
H L Muytjens, and
G L van Veldhuizen, and
G W Welling, and
J van der Ros-van de Repe, and
H B Boerema, and
D van der Waaij
February 1990,
BMJ (Clinical research ed.),
