-transparent.png){kind=logo}
There is clinical and experimental evidence to imply that urinary immunoglobulin light chains are nephrotoxic yet some patients pass large amounts for years with little renal damage. Animal experiments suggest that a light chain is more nephrotoxic if it has a high isoelectric point (i.e. is cationic in relation to urine pH). We studied 23 patients with multiple myeloma, measuring light chain excretion rate, light chain isoelectric point (pI) and creatinine clearance. Light chain excretion rate was independent of light chain isoelectric point and did not correlate with creatinine clearance. Light chain isoelectric point correlated with creatinine clearance, suggesting that this characteristic may be an important determinant of the nephrotoxic effect of these immunoglobulin constituents.
R A Coward, and
I W Delamore, and
N P Mallick, and
E L Robinson
January 1986,
The American journal of medicine,
R A Coward, and
I W Delamore, and
N P Mallick, and
E L Robinson
September 1984,
Clinical nephrology,
R A Coward, and
I W Delamore, and
N P Mallick, and
E L Robinson
May 1999,
Leukemia,
R A Coward, and
I W Delamore, and
N P Mallick, and
E L Robinson
February 2015,
Clinical chemistry,
R A Coward, and
I W Delamore, and
N P Mallick, and
E L Robinson
January 2007,
Asian Pacific journal of cancer prevention : APJCP,
R A Coward, and
I W Delamore, and
N P Mallick, and
E L Robinson
October 2018,
BMJ case reports,
R A Coward, and
I W Delamore, and
N P Mallick, and
E L Robinson
November 2014,
Leukemia,
R A Coward, and
I W Delamore, and
N P Mallick, and
E L Robinson
September 1979,
Kidney international,
R A Coward, and
I W Delamore, and
N P Mallick, and
E L Robinson
January 2002,
Clinical chemistry,
R A Coward, and
I W Delamore, and
N P Mallick, and
E L Robinson
January 1992,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
