BIOMAT Database Logo BIOMAT Database Logo

Respiratory infection of cyclophosphamide-treated mice with Pseudomonas aeruginosa. 1983

J D Rowatt, and J O Hill, and D L Lundgren

The dose of cyclophosphamide that permits the colonization of the nasopharynx with Pseudomonas aeruginosa and the survival of the animal was determined in mice. This dose, 100 mg/kg of cyclophosphamide, allowed P aeruginosa to colonize but not invade mouse nasal epithelium. Mice treated with 100 mg/kg cyclophosphamide were exposed to aerosol of 35S-labeled P aeruginosa to study clearance. Results indicated that this dose of cyclophosphamide suppressed both the pulmonary clearance of viable P aeruginosa (in situ killing) and the clearance of radiolabeled P aeruginosa (mechanical clearance).

UI MeSH Term Description Entries
D008168 Lung Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood. Lungs
D008297 Male Males
D009305 Nasopharynx The top portion of the pharynx situated posterior to the nose and superior to the SOFT PALATE. The nasopharynx is the posterior extension of the nasal cavities and has a respiratory function. Rhinopharynx,Choanae,Nasopharynges,Nasopharynxes,Rhinopharynges,Rhinopharynxes
D011550 Pseudomonas aeruginosa A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection. Bacillus aeruginosus,Bacillus pyocyaneus,Bacterium aeruginosum,Bacterium pyocyaneum,Micrococcus pyocyaneus,Pseudomonas polycolor,Pseudomonas pyocyanea
D011552 Pseudomonas Infections Infections with bacteria of the genus PSEUDOMONAS. Infections, Pseudomonas,Pseudomonas aeruginosa Infection,Infection, Pseudomonas,Pseudomonas Infection,Pseudomonas aeruginosa Infections
D012141 Respiratory Tract Infections Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases. Respiratory System Infections,Upper Respiratory Tract Infection,Upper Respiratory Tract Infections,Infections, Respiratory,Infections, Respiratory Tract,Infections, Upper Respiratory,Infections, Upper Respiratory Tract,Respiratory Infections,Upper Respiratory Infections,Infection, Respiratory System,Infection, Respiratory Tract,Respiratory Infection, Upper,Respiratory System Infection,Respiratory Tract Infection
D003520 Cyclophosphamide Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer. (+,-)-2-(bis(2-Chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-Oxide Monohydrate,B-518,Cyclophosphamide Anhydrous,Cyclophosphamide Monohydrate,Cyclophosphamide, (R)-Isomer,Cyclophosphamide, (S)-Isomer,Cyclophosphane,Cytophosphan,Cytophosphane,Cytoxan,Endoxan,NSC-26271,Neosar,Procytox,Sendoxan,B 518,B518,NSC 26271,NSC26271
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus

Related Publications

J D Rowatt, and J O Hill, and D L Lundgren
Fatal infection with Pseudomonas aeruginosa in mice treated with cyclophosphamide and Propionibacterium acnes.
January 1979, Jikken dobutsu. Experimental animals,
J D Rowatt, and J O Hill, and D L Lundgren
Pseudomonas aeruginosa infection in mice after treatment with cyclophosphamide.
December 1975, Archives of surgery (Chicago, Ill. : 1960),
J D Rowatt, and J O Hill, and D L Lundgren
Studies of lung infections caused by Pseudomonas aeruginosa in mice treated with cyclophosphamide.
January 1983, Infection,
J D Rowatt, and J O Hill, and D L Lundgren
[Protective effect of a corpuscular polyvalent Pseudomonas aeruginosa vaccine in generalized chronic Pseudomonas aeruginosa infection in mice with cyclophosphamide-induced leukopenia].
March 1986, Zhurnal mikrobiologii, epidemiologii i immunobiologii,
J D Rowatt, and J O Hill, and D L Lundgren
Experimental infection with Pseudomonas aeruginosa in mice. I. The virulence of Pseudomonas aeruginosa for mice.
July 1971, Japanese journal of microbiology,
J D Rowatt, and J O Hill, and D L Lundgren
Ciprofloxacin for respiratory tract infection with Pseudomonas aeruginosa.
December 1987, Pharmaceutisch weekblad. Scientific edition,
J D Rowatt, and J O Hill, and D L Lundgren
Vaccination against respiratory Pseudomonas aeruginosa infection.
January 2015, Human vaccines & immunotherapeutics,
J D Rowatt, and J O Hill, and D L Lundgren
Pseudomonas eye infections in cyclophosphamide-treated mice.
July 1977, Investigative ophthalmology & visual science,
J D Rowatt, and J O Hill, and D L Lundgren
Ciprofloxacin therapy of respiratory tract infection with Pseudomonas aeruginosa.
October 1988, European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology,
J D Rowatt, and J O Hill, and D L Lundgren
Effects of the beige mutation on respiratory tract infection with Pseudomonas aeruginosa in mice.
January 1994, Experimental lung research,
Copied contents to your clipboard!