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Fifty-five patients with acute myocardial infarction evaluated within 4 hours of the onset of symptoms were entered into an angiographically controlled trial of intracoronary streptokinase (IC STK). Forty-three patients with total occlusion of their infarct artery were randomized to either IC STK or intracoronary nitroglycerin (IC NTG), and 12 patients with less-than-complete occlusion received only IC NTG. Reperfusion of a totally occluded vessel was achieved in 69% of STK patients and 17% of IC NTG patients. Time from onset of symptoms to peak CK activity was significantly shorter in reperfused patients and patients with subtotal occlusion on initial angiography than in patients with total occlusion who were not reperfused (p less than 0.0001). Comparison of radionuclide ejection fractions (EF) determined acutely and 10 to 14 days after infarction failed to show improvement in either the STK or IC NTG group (mean decrease of 2.8% and 0.4%, respectively). In contrast, patients with subtotal occlusion on baseline angiography demonstrated a significant (p = 0.05) spontaneous improvement in EF over 2 weeks (7.3% increase).
R H Leiboff, and
R J Katz, and
A G Wasserman, and
G B Bren, and
H Schwartz, and
P J Varghese, and
A M Ross
December 1983,
The New England journal of medicine,
R H Leiboff, and
R J Katz, and
A G Wasserman, and
G B Bren, and
H Schwartz, and
P J Varghese, and
A M Ross
June 1983,
The New England journal of medicine,
R H Leiboff, and
R J Katz, and
A G Wasserman, and
G B Bren, and
H Schwartz, and
P J Varghese, and
A M Ross
November 1983,
Circulation,
R H Leiboff, and
R J Katz, and
A G Wasserman, and
G B Bren, and
H Schwartz, and
P J Varghese, and
A M Ross
October 1984,
Circulation,
R H Leiboff, and
R J Katz, and
A G Wasserman, and
G B Bren, and
H Schwartz, and
P J Varghese, and
A M Ross
February 1987,
Zhonghua xin xue guan bing za zhi,
R H Leiboff, and
R J Katz, and
A G Wasserman, and
G B Bren, and
H Schwartz, and
P J Varghese, and
A M Ross
June 1986,
American heart journal,
R H Leiboff, and
R J Katz, and
A G Wasserman, and
G B Bren, and
H Schwartz, and
P J Varghese, and
A M Ross
March 1985,
The New England journal of medicine,
R H Leiboff, and
R J Katz, and
A G Wasserman, and
G B Bren, and
H Schwartz, and
P J Varghese, and
A M Ross
November 1984,
Hawaii medical journal,
R H Leiboff, and
R J Katz, and
A G Wasserman, and
G B Bren, and
H Schwartz, and
P J Varghese, and
A M Ross
January 1986,
The American journal of cardiology,
R H Leiboff, and
R J Katz, and
A G Wasserman, and
G B Bren, and
H Schwartz, and
P J Varghese, and
A M Ross
February 1985,
The American journal of cardiology,
