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1. Minocycline (MNC) (10 mg/kg) and gentamicin (GM) (5 mg/kg), in combination with pre- or post-treatment, were intravenously injected to the rat or rabbit to investigate their pharmacokinetics. 2. The antibiotics in the samples were separated by the paper electrophoretic technique and their concentrations were determined by the cup thin-layer plate method using Bacillus subtilis as the test organism. 3. In the rat, the biological half life of MNC was shortened when combined with GM, and its initial level was elevated. On the other hand, the biological half life of GM was prolonged, and its initial level was decreased. Similar results were observed in the rabbit. 4. The urinary excretion rate of MNC in the rat was increased when combined with GM, while that of GM were decreased with MNC. 5. The biliary excretion rate of MNC in the rabbit was increased when combined with GM. 6. The binding rate of MNC to the serum proteins was apparently decreased when it was administered in combination with GM.
H Aratani, and
M Nakatsuka
November 1977,
Monatsschrift fur Kinderheilkunde,
H Aratani, and
M Nakatsuka
March 1976,
The Japanese journal of antibiotics,
H Aratani, and
M Nakatsuka
April 1976,
Arzneimittel-Forschung,
H Aratani, and
M Nakatsuka
June 1974,
The Japanese journal of antibiotics,
H Aratani, and
M Nakatsuka
January 1982,
The Japanese journal of antibiotics,
H Aratani, and
M Nakatsuka
January 1981,
Hiroshima Daigaku shigaku zasshi. The Journal of Hiroshima University Dental Society,
H Aratani, and
M Nakatsuka
June 1978,
Kokubyo Gakkai zasshi. The Journal of the Stomatological Society, Japan,
H Aratani, and
M Nakatsuka
June 1974,
Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica,
H Aratani, and
M Nakatsuka
July 1977,
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases,
H Aratani, and
M Nakatsuka
February 1979,
The Japanese journal of antibiotics,
