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The influence of nitrous oxide on the oxyhaemoglobin dissociation curve (ODC) was studied using blood from twenty healthy patients. When the blood samples were exposed to 50 per cent N2O during the determination of the ODC, a left shift was observed and the P50 was decreased by 1.06 kPa (8 mmHg). This shift cannot be explained by temperature, pH, PCO2, or 2,3-DPG effects. Following exposure of the blood to N2O-free gases, the shift disappeared rapidly, and a normal P50 (3.46 kPa) (26 mmHg) was reobtained. In keeping with this reversibility, blood samples taken before and during 45 minutes of N2O-curare anaesthesia showed identical dissociation curves to those which had been obtained during the in vitro N2O exposure experiment.
L Fournier, and
D Major
June 1970,
British journal of anaesthesia,
L Fournier, and
D Major
June 1986,
Anaesthesia,
L Fournier, and
D Major
February 1987,
Anesthesiology,
L Fournier, and
D Major
June 1975,
Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles,
L Fournier, and
D Major
April 2006,
Lancet (London, England),
L Fournier, and
D Major
March 1999,
Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine,
L Fournier, and
D Major
November 1976,
British journal of anaesthesia,
L Fournier, and
D Major
August 2003,
Anaesthesia and intensive care,
L Fournier, and
D Major
May 1990,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
