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In 10 patients who were treated with phenprocoumon (Marcumar) for thrombembolic diseases, we examined the influence of the combined therapy with diacepam (Valium) on the effect of the anticoagulant. After stopping the therapy with diacepam we saw a significant increase of the prothrombinetime (Quick) beyond the therapeutic level of 25%. By increasing the dosis of phenprocoumon the therapeutic level was achieved again not until after 8 days. The dosis needed for maintaining this level was on the average 32% higher than during the time of the therapy in which diacepam was used. Because of the increased thrombembolic risk, when going beyond the therapeutic level of the prothrombinetime, this interaction is of clinical importance.
C Schunter, and
H Held, and
R Schmülling
September 1975,
Deutsche medizinische Wochenschrift (1946),
C Schunter, and
H Held, and
R Schmülling
January 1979,
Der Anaesthesist,
C Schunter, and
H Held, and
R Schmülling
January 1976,
Arzneimittel-Forschung,
C Schunter, and
H Held, and
R Schmülling
May 1978,
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie,
C Schunter, and
H Held, and
R Schmülling
January 1973,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
C Schunter, and
H Held, and
R Schmülling
February 1980,
MMW, Munchener medizinische Wochenschrift,
C Schunter, and
H Held, and
R Schmülling
April 1974,
Klinische Monatsblatter fur Augenheilkunde,
C Schunter, and
H Held, and
R Schmülling
June 1971,
Postgraduate medical journal,
C Schunter, and
H Held, and
R Schmülling
November 2021,
The Journal of international medical research,
C Schunter, and
H Held, and
R Schmülling
August 1970,
British journal of anaesthesia,
