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The method of pulsatile administration of gonadotropin-releasing hormone (Gn-RH) has been proven as a useful means for induction of ovulation in anovulatory women. In our series of clinical trials, 23 out of 29 anovulatory patients ovulated with pulsatile administration of Gn-RH. Seven patients who ovulated volunteered for the present study with daily hormonal analysis and follicular sonometory . Two patients have oligomenorrhea, 3 patients secondary amenorrhea-1st grade (the sole administration of gestagen required for withdrawal bleeding) and the remaining 2 patients secondary amenorrhea-2nd grade (the combined administration of estrogen and gestagen required for withdrawal bleeding). A diagnosis of hyperprolactinemia was made for one patient with secondary amenorrhea-1st grade. Pulsatile administration of Gn-RH was performed by the use of a self-administered infuser . The infuser was connected to an i.v. indwelling catheter via a specially designed blood backflow eliminater . Five micrograms or less of Gn-RH was given every 2 hr from 07:00 to 23:00 hr daily. Five patients received HCG during the preovulatory period. In one patient, a short term treatment of HMG was added to Gn-RH treatment. Follicular sonometry revealed the development of a single dominant follicle which reached between 20 and 28 mm (23.7 +/- 0.12 mm, mean +/- S.E.) in diameter at the preovulatory period. Disappearance of a dominant follicle was recognized in the early luteal phase. Characteristic increases in estradiol were recognized concomitantly with the development of a dominant follicle. Progesterone levels after ovulation were within the limits of its normal "luteal phase" rise. The present data suggest that pulsatile administration of low dose Gn-RH with nocturnal interruption of treatment is effective for normal progress of follicular development in various types of anovulatory patients, culminating in single ovulation. This paper includes the discussion on our method which may be responsible for a high success rate of ovulation induction.
S Araki, and
K Chikazawa, and
T Ohkusa, and
K Ijima, and
K Usui, and
M Motoyama, and
T Tamada
September 1983,
Journal of reproduction and fertility,
S Araki, and
K Chikazawa, and
T Ohkusa, and
K Ijima, and
K Usui, and
M Motoyama, and
T Tamada
January 1988,
Zentralblatt fur Gynakologie,
S Araki, and
K Chikazawa, and
T Ohkusa, and
K Ijima, and
K Usui, and
M Motoyama, and
T Tamada
March 1993,
Minerva ginecologica,
S Araki, and
K Chikazawa, and
T Ohkusa, and
K Ijima, and
K Usui, and
M Motoyama, and
T Tamada
January 1984,
Upsala journal of medical sciences,
S Araki, and
K Chikazawa, and
T Ohkusa, and
K Ijima, and
K Usui, and
M Motoyama, and
T Tamada
January 1984,
Acta Europaea fertilitatis,
S Araki, and
K Chikazawa, and
T Ohkusa, and
K Ijima, and
K Usui, and
M Motoyama, and
T Tamada
June 1984,
Nihon Sanka Fujinka Gakkai zasshi,
S Araki, and
K Chikazawa, and
T Ohkusa, and
K Ijima, and
K Usui, and
M Motoyama, and
T Tamada
January 1984,
Acta Europaea fertilitatis,
S Araki, and
K Chikazawa, and
T Ohkusa, and
K Ijima, and
K Usui, and
M Motoyama, and
T Tamada
July 1983,
Nihon Sanka Fujinka Gakkai zasshi,
S Araki, and
K Chikazawa, and
T Ohkusa, and
K Ijima, and
K Usui, and
M Motoyama, and
T Tamada
July 1986,
Fertility and sterility,
S Araki, and
K Chikazawa, and
T Ohkusa, and
K Ijima, and
K Usui, and
M Motoyama, and
T Tamada
January 1982,
Journal de gynecologie, obstetrique et biologie de la reproduction,
