Red blood cell hexokinase in Fanconi's anemia. 1984

M Magnani, and G Novelli, and V Stocchi, and G Alimena, and B Dallapiccola

The activity of ten red blood cell enzymes, including hexokinase, has been measured in 6 Fanconi's anemia patients. In disagreement with previous reports, in no instance were reduced or increased hexokinase levels found. Furthermore, the hexokinase isozymic pattern, thermostability, pH dependence of activity and kinetic properties were also in the normal range.

UI MeSH Term Description Entries
D007527 Isoenzymes Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics. Alloenzyme,Allozyme,Isoenzyme,Isozyme,Isozymes,Alloenzymes,Allozymes
D008297 Male Males
D004912 Erythrocytes Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN. Blood Cells, Red,Blood Corpuscles, Red,Red Blood Cells,Red Blood Corpuscles,Blood Cell, Red,Blood Corpuscle, Red,Erythrocyte,Red Blood Cell,Red Blood Corpuscle
D005199 Fanconi Anemia Congenital disorder affecting all bone marrow elements, resulting in ANEMIA; LEUKOPENIA; and THROMBOPENIA, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. Spontaneous CHROMOSOME BREAKAGE is a feature of this disease along with predisposition to LEUKEMIA. There are at least 7 complementation groups in Fanconi anemia: FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, and FANCL. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id Anemia, Fanconi,Fanconi Hypoplastic Anemia,Fanconi Pancytopenia,Fanconi Panmyelopathy,Fanconi's Anemia,Anemia, Fanconi's,Anemias, Fanconi,Fanconi Anemias
D005260 Female Females
D006593 Hexokinase An enzyme that catalyzes the conversion of ATP and a D-hexose to ADP and a D-hexose 6-phosphate. D-Glucose, D-mannose, D-fructose, sorbitol, and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. (From Enzyme Nomenclature, 1992) EC 2.7.1.1. Hexokinase A,Hexokinase D,Hexokinase II
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000741 Anemia, Aplastic A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. Anemia, Hypoplastic,Aplastic Anaemia,Aplastic Anemia,Anaemia, Aplastic,Aplastic Anaemias,Aplastic Anemias,Hypoplastic Anemia,Hypoplastic Anemias

Related Publications

M Magnani, and G Novelli, and V Stocchi, and G Alimena, and B Dallapiccola
January 1972, The Mount Sinai journal of medicine, New York,
M Magnani, and G Novelli, and V Stocchi, and G Alimena, and B Dallapiccola
January 1966, Humangenetik,
M Magnani, and G Novelli, and V Stocchi, and G Alimena, and B Dallapiccola
December 1982, Molecular and cellular biochemistry,
M Magnani, and G Novelli, and V Stocchi, and G Alimena, and B Dallapiccola
September 1994, Cell biochemistry and function,
M Magnani, and G Novelli, and V Stocchi, and G Alimena, and B Dallapiccola
June 1983, Tumori,
M Magnani, and G Novelli, and V Stocchi, and G Alimena, and B Dallapiccola
April 1971, JAMA,
M Magnani, and G Novelli, and V Stocchi, and G Alimena, and B Dallapiccola
July 1981, Archives of dermatology,
M Magnani, and G Novelli, and V Stocchi, and G Alimena, and B Dallapiccola
February 1980, The Journal of biological chemistry,
M Magnani, and G Novelli, and V Stocchi, and G Alimena, and B Dallapiccola
January 1981, The Italian journal of biochemistry,
M Magnani, and G Novelli, and V Stocchi, and G Alimena, and B Dallapiccola
August 1982, Cancer,
Copied contents to your clipboard!