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The authors conducted a double-blind prospective study of 39 patients with unipolar endogenous depression who recovered after ECT. Thyrotropin (TSH)-releasing hormone (TRH) tests were performed before and after ECT. Patients were divided into three groups on the basis of their altered TSH response: Persistent remission was predicted for patients in group 1 (N = 15) and relapse was predicted for groups 2A (N = 13) and 2B (N = 11). Patients in groups 1 and 2A received placebo and those in group 2B received amitriptyline for 6 months. Fewer relapses occurred in groups 1 and 2B than in group 2A (p less than .05), showing that relapse can be predicted by the TRH test and prevented by amitriptyline.
I Krog-Meyer, and
C Kirkegaard, and
B Kijne, and
B Lumholtz, and
E Smith, and
L Lykke-Olesen, and
N Bjørum
April 1980,
The New England journal of medicine,
I Krog-Meyer, and
C Kirkegaard, and
B Kijne, and
B Lumholtz, and
E Smith, and
L Lykke-Olesen, and
N Bjørum
August 1978,
Psychological medicine,
I Krog-Meyer, and
C Kirkegaard, and
B Kijne, and
B Lumholtz, and
E Smith, and
L Lykke-Olesen, and
N Bjørum
July 1979,
Psychoneuroendocrinology,
I Krog-Meyer, and
C Kirkegaard, and
B Kijne, and
B Lumholtz, and
E Smith, and
L Lykke-Olesen, and
N Bjørum
February 1981,
Nihon Ika Daigaku zasshi,
I Krog-Meyer, and
C Kirkegaard, and
B Kijne, and
B Lumholtz, and
E Smith, and
L Lykke-Olesen, and
N Bjørum
November 1980,
Acta psychiatrica Scandinavica,
I Krog-Meyer, and
C Kirkegaard, and
B Kijne, and
B Lumholtz, and
E Smith, and
L Lykke-Olesen, and
N Bjørum
January 1989,
Psychiatria polska,
I Krog-Meyer, and
C Kirkegaard, and
B Kijne, and
B Lumholtz, and
E Smith, and
L Lykke-Olesen, and
N Bjørum
September 1987,
Psychiatry research,
I Krog-Meyer, and
C Kirkegaard, and
B Kijne, and
B Lumholtz, and
E Smith, and
L Lykke-Olesen, and
N Bjørum
March 1982,
Journal of affective disorders,
I Krog-Meyer, and
C Kirkegaard, and
B Kijne, and
B Lumholtz, and
E Smith, and
L Lykke-Olesen, and
N Bjørum
September 1982,
Pharmacopsychiatria,
I Krog-Meyer, and
C Kirkegaard, and
B Kijne, and
B Lumholtz, and
E Smith, and
L Lykke-Olesen, and
N Bjørum
January 1980,
Lancet (London, England),
