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As it is known that platelets play an important role in arising and maintaining the inflammation, the authors have studied "in vitro", the effect on platelet aggregation of three drugs (Sodium Aurothiomalate, Auranofin and Penicillamine) used in basic therapy of Rheumatoid Arthritis (RA). The drugs are used in different concentrations and at different times of preincubation. The study was based on the principle of Born and using the Coagg-Salus aggregometer. The platelet aggregation was induced by ADP 2.5 microM. The authors have demonstrated that the above-named drugs inhibit the platelet aggregation induced by ADP in different percentile, according to the concentrations adopted and the time of preincubation with platelets rich plasma. This study seems particularly interesting because it can offer a possible interpretation on the mechanism of action of basic therapy in RA.
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V Lolatte, and
N Giordano, and
E Frati, and
M L Castagna, and
G Morozzi, and
M Lalumera, and
R Marcolongo
July 1985,
Arthritis and rheumatism,
A Fioravanti, and
V Lolatte, and
N Giordano, and
E Frati, and
M L Castagna, and
G Morozzi, and
M Lalumera, and
R Marcolongo
March 1977,
Ryumachi. [Rheumatism],
A Fioravanti, and
V Lolatte, and
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G Morozzi, and
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R Marcolongo
May 1990,
Comprehensive therapy,
A Fioravanti, and
V Lolatte, and
N Giordano, and
E Frati, and
M L Castagna, and
G Morozzi, and
M Lalumera, and
R Marcolongo
January 1999,
Comprehensive therapy,
A Fioravanti, and
V Lolatte, and
N Giordano, and
E Frati, and
M L Castagna, and
G Morozzi, and
M Lalumera, and
R Marcolongo
January 1994,
Terapevticheskii arkhiv,
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January 1988,
Terapevticheskii arkhiv,
A Fioravanti, and
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G Morozzi, and
M Lalumera, and
R Marcolongo
October 1981,
Medizinische Klinik,
A Fioravanti, and
V Lolatte, and
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M L Castagna, and
G Morozzi, and
M Lalumera, and
R Marcolongo
July 1977,
Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete,
A Fioravanti, and
V Lolatte, and
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M L Castagna, and
G Morozzi, and
M Lalumera, and
R Marcolongo
January 1975,
Series haematologica (1968),
A Fioravanti, and
V Lolatte, and
N Giordano, and
E Frati, and
M L Castagna, and
G Morozzi, and
M Lalumera, and
R Marcolongo
September 1973,
Experientia,
