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A prospective randomized trial was conducted comparing the clinical response of 60 patients with advanced breast cancer to a combination of adriamycin, cyclophosphamide, and oral ftorafur (ACF), or to a combination of ACF plus methotrexate (ACFM). The response rate was 12 of 28 (43%) in ACF and 18 of 30 (60%) in ACFM. Responses were seen more frequently in patients in whom fewer than two organs were involved, and responses at dominant metastatic sites were equal for the two arms. The response duration was 21 + (3.5-49.5+) months with ACF, as against 6.9 (1.9-30.8+) months with ACFM (P less than 0.05). The median survival time from start of therapy was 20.8+ months for ACF, while that for ACFM was 13+ months (statistically not significant). The major toxicities were hair loss, GI toxicity, and leukopenia. The response rate with ACFM was higher than that with ACF, but the addition of methotrexate to ACF did not increase the complete response rate or prolong response duration.
K Inoue, and
M Ogawa, and
J Inagaki, and
N Horikoshi, and
H Miyamoto, and
K Ikeda, and
N Usui, and
H Nakada, and
K Adachi
January 1983,
Orvosi hetilap,
K Inoue, and
M Ogawa, and
J Inagaki, and
N Horikoshi, and
H Miyamoto, and
K Ikeda, and
N Usui, and
H Nakada, and
K Adachi
October 1981,
Cancer,
K Inoue, and
M Ogawa, and
J Inagaki, and
N Horikoshi, and
H Miyamoto, and
K Ikeda, and
N Usui, and
H Nakada, and
K Adachi
August 1979,
Cancer,
K Inoue, and
M Ogawa, and
J Inagaki, and
N Horikoshi, and
H Miyamoto, and
K Ikeda, and
N Usui, and
H Nakada, and
K Adachi
November 1978,
Cancer,
K Inoue, and
M Ogawa, and
J Inagaki, and
N Horikoshi, and
H Miyamoto, and
K Ikeda, and
N Usui, and
H Nakada, and
K Adachi
April 1981,
Cancer,
K Inoue, and
M Ogawa, and
J Inagaki, and
N Horikoshi, and
H Miyamoto, and
K Ikeda, and
N Usui, and
H Nakada, and
K Adachi
January 1982,
Lijecnicki vjesnik,
K Inoue, and
M Ogawa, and
J Inagaki, and
N Horikoshi, and
H Miyamoto, and
K Ikeda, and
N Usui, and
H Nakada, and
K Adachi
May 1987,
Presse medicale (Paris, France : 1983),
K Inoue, and
M Ogawa, and
J Inagaki, and
N Horikoshi, and
H Miyamoto, and
K Ikeda, and
N Usui, and
H Nakada, and
K Adachi
May 1979,
Cancer,
K Inoue, and
M Ogawa, and
J Inagaki, and
N Horikoshi, and
H Miyamoto, and
K Ikeda, and
N Usui, and
H Nakada, and
K Adachi
January 1985,
Cancer chemotherapy and pharmacology,
K Inoue, and
M Ogawa, and
J Inagaki, and
N Horikoshi, and
H Miyamoto, and
K Ikeda, and
N Usui, and
H Nakada, and
K Adachi
January 1986,
Cancer chemotherapy and pharmacology,
