-transparent.png){kind=logo}
Six male prepubertal children with constitutional growth delay (CGD), and a subnormal growth hormone (GH) response to insulin hypoglycemia, and four normal prepubertal children were given in different occasions 1 microgram/Kg iv synthetic hpGRF-40 or a single oral dose of 0.15 mg/m2 clonidine (Clon), an effective growth hormone (GH) secretagogue. In the normal children brisk and clear-cut GH rises were detected in plasma after hpGRF-40 (peak GH levels at 15-30 min) or clonidine (peak GH levels 60-90 min). In CGD children hpGRF-40 induced a biphasic response, e.g. a slight increase in plasma GH at 15 min followed by a delayed and erratic GH rise occurring 45-120 min post-injection. Also the GH response to Clon was sluggish and delayed and peak plasma GH levels were attained only 90-180 min post-drug administration. These data indicate that the CGD children of our study have a defect in the pituitary GH reserve.
C Pintor, and
R Puggioni, and
V Fanni, and
S G Cella, and
A Villa, and
V Locatelli, and
E E Müller
February 1991,
Journal of endocrinological investigation,
C Pintor, and
R Puggioni, and
V Fanni, and
S G Cella, and
A Villa, and
V Locatelli, and
E E Müller
November 1986,
The Journal of pediatrics,
C Pintor, and
R Puggioni, and
V Fanni, and
S G Cella, and
A Villa, and
V Locatelli, and
E E Müller
January 1992,
Zhonghua Minguo xiao er ke yi xue hui za zhi [Journal]. Zhonghua Minguo xiao er ke yi xue hui,
C Pintor, and
R Puggioni, and
V Fanni, and
S G Cella, and
A Villa, and
V Locatelli, and
E E Müller
January 1986,
Revista chilena de pediatria,
C Pintor, and
R Puggioni, and
V Fanni, and
S G Cella, and
A Villa, and
V Locatelli, and
E E Müller
March 1993,
Neuroendocrinology,
C Pintor, and
R Puggioni, and
V Fanni, and
S G Cella, and
A Villa, and
V Locatelli, and
E E Müller
April 1990,
Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde,
C Pintor, and
R Puggioni, and
V Fanni, and
S G Cella, and
A Villa, and
V Locatelli, and
E E Müller
January 1988,
Acta paediatrica Japonica : Overseas edition,
C Pintor, and
R Puggioni, and
V Fanni, and
S G Cella, and
A Villa, and
V Locatelli, and
E E Müller
January 1990,
Panminerva medica,
C Pintor, and
R Puggioni, and
V Fanni, and
S G Cella, and
A Villa, and
V Locatelli, and
E E Müller
December 1982,
Proceedings of the National Academy of Sciences of the United States of America,
C Pintor, and
R Puggioni, and
V Fanni, and
S G Cella, and
A Villa, and
V Locatelli, and
E E Müller
January 1986,
Acta endocrinologica. Supplementum,
