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We gave graded doses of levothyroxine sodium to 11 elderly hypothyroid subjects (mean age, 66.1 years). The daily levothyroxine sodium dose was initially 75 micrograms or less, and was increased by 25 micrograms every six weeks. Serum total thyroxine, total triiodothyronine, and basal thyrotropin levels were measured at the start of the study and at the end of each six-week dose period. A protirelin (thyrotropin-releasing hormone) test was performed when the thyrotropin level returned to normal. Mean daily levothyroxine sodium doses that normalized serum thyrotropin levels and protirelin test were 110 +/- 8 micrograms and 113 +/- 9 micrograms, respectively. Serial basal thyrotropin determinations during stepwise increments in levothyroxine dose indicated physiologic hormone replacement. As determined in our elderly patients, levothyroxine replacement dose was a third less than that formerly recommended.
F B Davis, and
R S LaMantia, and
S W Spaulding, and
R E Wehmann, and
P J Davis
January 2021,
Frontiers in endocrinology,
F B Davis, and
R S LaMantia, and
S W Spaulding, and
R E Wehmann, and
P J Davis
January 1982,
Annals of internal medicine,
F B Davis, and
R S LaMantia, and
S W Spaulding, and
R E Wehmann, and
P J Davis
May 1987,
The Journal of family practice,
F B Davis, and
R S LaMantia, and
S W Spaulding, and
R E Wehmann, and
P J Davis
July 2019,
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists,
F B Davis, and
R S LaMantia, and
S W Spaulding, and
R E Wehmann, and
P J Davis
January 2006,
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists,
F B Davis, and
R S LaMantia, and
S W Spaulding, and
R E Wehmann, and
P J Davis
December 2016,
Journal of clinical and diagnostic research : JCDR,
F B Davis, and
R S LaMantia, and
S W Spaulding, and
R E Wehmann, and
P J Davis
January 1999,
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists,
F B Davis, and
R S LaMantia, and
S W Spaulding, and
R E Wehmann, and
P J Davis
March 1999,
The Journal of clinical endocrinology and metabolism,
F B Davis, and
R S LaMantia, and
S W Spaulding, and
R E Wehmann, and
P J Davis
February 2006,
Medicina clinica,
F B Davis, and
R S LaMantia, and
S W Spaulding, and
R E Wehmann, and
P J Davis
March 1999,
Pharmacotherapy,
