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The present study shows that recombinant interleukin 2 (IL-2) purified to homogeneity induces a rapid and potent enhancement of spontaneous cytotoxicity of human peripheral blood lymphocytes. The cells mediating cytotoxicity after 18-h treatment with IL-2 have surface markers of natural killer (NK) cells and are generated from the peripheral blood subset containing spontaneous cytotoxic cells. A parallel production of gamma interferon (IFN-gamma) is induced by recombinant IL-2 (rIL-2), and NK cells appear to be the major producer cells, whereas T cells are unable to produce IFN-gamma under these experimental conditions. However, the kinetics of the enhancement of cytotoxicity are faster than those of IFN-gamma production, and monoclonal anti-IFN-gamma antibodies do not suppress this effect, making it unlikely that the IFN-gamma produced is responsible for the enhancement. The enhancement of NK cell activity induced by rIL-2 precedes any proliferative response of the lymphocytes, which is instead observed in longer-term cultures of both NK and T cells.
G Trinchieri, and
M Matsumoto-Kobayashi, and
S C Clark, and
J Seehra, and
L London, and
B Perussia
January 2004,
Journal of endocrinological investigation,
G Trinchieri, and
M Matsumoto-Kobayashi, and
S C Clark, and
J Seehra, and
L London, and
B Perussia
January 1991,
Cellular immunology,
G Trinchieri, and
M Matsumoto-Kobayashi, and
S C Clark, and
J Seehra, and
L London, and
B Perussia
July 1988,
The Journal of experimental medicine,
G Trinchieri, and
M Matsumoto-Kobayashi, and
S C Clark, and
J Seehra, and
L London, and
B Perussia
January 1996,
Dementia (Basel, Switzerland),
G Trinchieri, and
M Matsumoto-Kobayashi, and
S C Clark, and
J Seehra, and
L London, and
B Perussia
March 1994,
Asia-Oceania journal of obstetrics and gynaecology,
G Trinchieri, and
M Matsumoto-Kobayashi, and
S C Clark, and
J Seehra, and
L London, and
B Perussia
January 2005,
Advances in immunology,
G Trinchieri, and
M Matsumoto-Kobayashi, and
S C Clark, and
J Seehra, and
L London, and
B Perussia
June 1982,
The Journal of experimental medicine,
G Trinchieri, and
M Matsumoto-Kobayashi, and
S C Clark, and
J Seehra, and
L London, and
B Perussia
February 1993,
Lymphokine and cytokine research,
G Trinchieri, and
M Matsumoto-Kobayashi, and
S C Clark, and
J Seehra, and
L London, and
B Perussia
January 2000,
International journal of immunopharmacology,
G Trinchieri, and
M Matsumoto-Kobayashi, and
S C Clark, and
J Seehra, and
L London, and
B Perussia
January 2005,
Methods in molecular medicine,
