Biomaterial Database

Ventilatory response to CO2. I. A psychobiologic marker of the respiratory system. 1984

B S Singh

When a gas mixture containing CO2 is breathed by a healthy subject, alveolar ventilation is increased. The ratio delta ventilation/delta PCO2 has been termed the ventilatory response to CO2 (S). Since the development of a rebreathing method in 1967, it has proved easy to measure this index of the regulation of ventilation. This index, although showing considerable interindividual variation (range, 0.5-9 liters/min/mm PCO2), tends to be consistent over time for any given individual. Positive correlations between S and personality traits such as anxiety, extroversion, and aggression and negative correlations between S and certain scales of the Minnesota Multiphasic Personality Inventory (MMPI: depression, psychopathology, psychasthenia, and social introversion) have been found in previous studies. It was hypothesized that S may be a psychobiologic marker of the respiratory system. A project in which 82 normal subjects (50 male, 32 female) were studied with both psychologic (Eysenck Personality Inventory, Catell 16PF, and 168-item MMPI) and rebreathing tests was undertaken to investigate this possibility further. A strong correlation between S and neurotic personality traits was found, but this correlation appeared valid only in female subjects.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008950	MMPI	A personality inventory consisting of statements to be asserted or denied by the individual. The patterns of response are characteristic of certain personality attributes.	Minnesota Multiphasic Personality Inventory
D009497	Neurotic Disorders	Disorders in which the symptoms are distressing to the individual and recognized by him or her as being unacceptable. Social relationships may be greatly affected but usually remain within acceptable limits. The disturbance is relatively enduring or recurrent without treatment.	Neuroses,Psychoneuroses,Disorder, Neurotic,Disorders, Neurotic,Neurotic Disorder
D010551	Personality	Behavior-response patterns that characterize the individual.	Personalities
D010555	Personality Inventory	Check list, usually to be filled out by a person about himself, consisting of many statements about personal characteristics which the subject checks.	Edwards Personal Preference Schedule,Myers-Briggs Type Indicator,Indicator, Myers-Briggs Type,Inventories, Personality,Inventory, Personality,Myers Briggs Type Indicator,Personality Inventories
D012119	Respiration	The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (	Breathing
D002245	Carbon Dioxide	A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.	Carbonic Anhydride,Anhydride, Carbonic,Dioxide, Carbon
D003863	Depression	Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.	Depressive Symptoms,Emotional Depression,Depression, Emotional,Depressive Symptom,Symptom, Depressive
D005120	Extraversion, Psychological	A state in which attention is largely directed outward from the self.	Extraversion (Psychology),Extraversion, Psychology,Extroversion, Psychological,Extroversion, Psychology,Extraversion,Extroversion,Extroversion (Psychology),Psychological Extraversion,Psychological Extroversion,Psychology Extraversion,Psychology Extraversions,Psychology Extroversion
D005260	Female		Females