On 24 patients with ascertained hypertrophic obstructive cardiomyopathy and hypertrophic non-obstructive cardiomyopathy in a long-term experiment over 6 months the effect of 30 mg Nifedipin per day on subjective and objective parameters was investigated and compared with Propranolol. The subjective symptoms were in a larger extent improved by Propranolol than by Nifedipin. In contrast to Propranolol Nifedipin had no influence on the systolic function on the basis of the systolic time intervals. The diastolic heart function, assessed by means of the cardiographic criteria of the apex, was improved by Nifedipin in circa the same extent as by Propranolol. The results altogether allow the conclusion that the application of Nifedipin seems to be reasonable in patients with contraindication to beta-receptor-blockers or Verapamil or when there is no reaction to these preparations. When there is no satisfying result, a combination with beta-blockers should also be attempted.