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The effect of acetylsalicylic acid (ASA, 3 g/day for 3 days) and of indomethacin (IND, 150 mg/day for 3 days) on diuresis and on the excretion of prostaglandin E2 (PGE2) was studied in six healthy, male volunteers. After overnight deprivation the subjects received an oral water load (20 ml/kg) and hourly urine volumes were replaced by an equivalent volume of water by mouth for 4 h. Pretreatment with both ASA and IND induced a comparable suppression (P less than 0.05 to less than 0.001) in the excretion of PGE2, but only IND also reduced (P less than 0.05) diuresis, free water clearance and the excretion of sodium. The excretion of creatinine was uninfluenced by both ASA and IND. These data indicate that a mechanism other than cyclo-oxygenase inhibition is involved in the effect of IND and ASA on diuresis in man.
H Vierhapper, and
J Jörg, and
W Waldhäusl
November 1982,
Gastroenterology,
H Vierhapper, and
J Jörg, and
W Waldhäusl
July 1983,
Acta physiologica Scandinavica,
H Vierhapper, and
J Jörg, and
W Waldhäusl
January 1992,
Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia,
H Vierhapper, and
J Jörg, and
W Waldhäusl
December 1980,
Agents and actions,
H Vierhapper, and
J Jörg, and
W Waldhäusl
February 1977,
Metabolism: clinical and experimental,
H Vierhapper, and
J Jörg, and
W Waldhäusl
June 1978,
Vrachebnoe delo,
H Vierhapper, and
J Jörg, and
W Waldhäusl
December 1994,
Agents and actions,
H Vierhapper, and
J Jörg, and
W Waldhäusl
January 1987,
Progress in clinical and biological research,
H Vierhapper, and
J Jörg, and
W Waldhäusl
January 1985,
Proceedings of the Finnish Dental Society. Suomen Hammaslaakariseuran toimituksia,
H Vierhapper, and
J Jörg, and
W Waldhäusl
August 1979,
Acta endocrinologica,
