-transparent.png){kind=logo}
Supernatants from clones of human T lymphocytes that were responding to a purified Mycobacterium tuberculosis antigen were able to activate macrophages and macrophage-like myeloma cells (U937) to release increased amounts of the microbicidal agent hydrogen peroxide. The activity was not neutralized by monoclonal antibody against interferon-gamma (IFN-gamma), was greater than could be accounted for by the IFN-gamma activity in the supernatants, and was separated from IFN-gamma by high performance liquid chromatography. It is evident that IFN-gamma is not the only macrophage activator released by T lymphocytes responding to microbial antigen, and may not even be the main one to enhance antimicrobial activity in infections such as tuberculosis.
P W Andrew, and
A D Rees, and
A Scoging, and
N Dobson, and
R Matthews, and
J T Whittall, and
A R Coates, and
D B Lowrie
August 1983,
Journal of immunology (Baltimore, Md. : 1950),
P W Andrew, and
A D Rees, and
A Scoging, and
N Dobson, and
R Matthews, and
J T Whittall, and
A R Coates, and
D B Lowrie
June 1984,
Journal of immunology (Baltimore, Md. : 1950),
P W Andrew, and
A D Rees, and
A Scoging, and
N Dobson, and
R Matthews, and
J T Whittall, and
A R Coates, and
D B Lowrie
October 1984,
Cancer research,
P W Andrew, and
A D Rees, and
A Scoging, and
N Dobson, and
R Matthews, and
J T Whittall, and
A R Coates, and
D B Lowrie
December 1986,
European journal of immunology,
P W Andrew, and
A D Rees, and
A Scoging, and
N Dobson, and
R Matthews, and
J T Whittall, and
A R Coates, and
D B Lowrie
August 1983,
Journal of immunology (Baltimore, Md. : 1950),
P W Andrew, and
A D Rees, and
A Scoging, and
N Dobson, and
R Matthews, and
J T Whittall, and
A R Coates, and
D B Lowrie
May 1988,
Cellular immunology,
P W Andrew, and
A D Rees, and
A Scoging, and
N Dobson, and
R Matthews, and
J T Whittall, and
A R Coates, and
D B Lowrie
January 1989,
European journal of immunology,
P W Andrew, and
A D Rees, and
A Scoging, and
N Dobson, and
R Matthews, and
J T Whittall, and
A R Coates, and
D B Lowrie
January 1986,
Ciba Foundation symposium,
P W Andrew, and
A D Rees, and
A Scoging, and
N Dobson, and
R Matthews, and
J T Whittall, and
A R Coates, and
D B Lowrie
January 1985,
Immunology,
P W Andrew, and
A D Rees, and
A Scoging, and
N Dobson, and
R Matthews, and
J T Whittall, and
A R Coates, and
D B Lowrie
January 1982,
Advances in experimental medicine and biology,
