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Because most men with prenatal exposure to diethylstilbestrol (DES) are still young and have not attempted to father children, its reproductive effects are uncertain. In a previous pilot study, we had noted an association between in utero DES exposure and reduced penetration of zona-free hamster eggs by sperm. To test these findings in a controlled manner, we performed physical examinations on 51 men with in utero DES exposure and 29 unexposed men and evaluated the penetration of zona-free hamster eggs by their sperm. Epididymal cysts or abnormalities of the prostate, testicle, or penile meatus were present in 37% of men with in utero DES exposure, versus 4% of nonexposed men (P less than 0.001). The mean proportions of penetrated eggs were 25% after in utero DES exposure and 29% in the nonexposed group (P greater than 0.57). The genital abnormalities related to DES exposure were not related to reduced egg penetration. We conclude that in utero exposure to DES is not related to a significant change in the penetration of zona-free hamster eggs by sperm.
K K Shy, and
M A Stenchever, and
L E Karp, and
R E Berger, and
R A Williamson, and
J Leonard
January 1987,
Reproductive toxicology (Elmsford, N.Y.),
K K Shy, and
M A Stenchever, and
L E Karp, and
R E Berger, and
R A Williamson, and
J Leonard
August 1985,
International journal of andrology,
K K Shy, and
M A Stenchever, and
L E Karp, and
R E Berger, and
R A Williamson, and
J Leonard
March 1980,
Fertility and sterility,
K K Shy, and
M A Stenchever, and
L E Karp, and
R E Berger, and
R A Williamson, and
J Leonard
June 1980,
American journal of obstetrics and gynecology,
K K Shy, and
M A Stenchever, and
L E Karp, and
R E Berger, and
R A Williamson, and
J Leonard
January 1986,
Zeitschrift fur mikroskopisch-anatomische Forschung,
K K Shy, and
M A Stenchever, and
L E Karp, and
R E Berger, and
R A Williamson, and
J Leonard
May 1985,
Seminars in urology,
K K Shy, and
M A Stenchever, and
L E Karp, and
R E Berger, and
R A Williamson, and
J Leonard
December 1988,
Fertility and sterility,
K K Shy, and
M A Stenchever, and
L E Karp, and
R E Berger, and
R A Williamson, and
J Leonard
January 1989,
Archives of andrology,
K K Shy, and
M A Stenchever, and
L E Karp, and
R E Berger, and
R A Williamson, and
J Leonard
April 2001,
Journal of the National Cancer Institute,
K K Shy, and
M A Stenchever, and
L E Karp, and
R E Berger, and
R A Williamson, and
J Leonard
March 1978,
Israel journal of medical sciences,
