-transparent.png){kind=logo}
The administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (1-4 mg/kg i.p.) for 4 days induced dose-dependent parkinsonism in the common marmoset within 48 h. MPTP produced profound akinesia, rigidity of the trunk and limbs, postural abnormalities, loss of vocalization and, in some cases, postural tremor. In a single animal the administration of L-DOPA in conjunction with a peripheral decarboxylase inhibitor, reversed the parkinsonian symptoms. Subsequent biochemical analysis showed a profound loss of dopamine and [3H]dopamine uptake in the caudate-putamen, but no change in specific [3H]spiperone binding.
Related Publications
P Jenner, and
N M Rupniak, and
S Rose, and
E Kelly, and
G Kilpatrick, and
A Lees, and
C D Marsden
August 1994,
Neuroscience letters,
P Jenner, and
N M Rupniak, and
S Rose, and
E Kelly, and
G Kilpatrick, and
A Lees, and
C D Marsden
August 1992,
Journal of neurochemistry,
P Jenner, and
N M Rupniak, and
S Rose, and
E Kelly, and
G Kilpatrick, and
A Lees, and
C D Marsden
February 2013,
Neuropathology and applied neurobiology,
P Jenner, and
N M Rupniak, and
S Rose, and
E Kelly, and
G Kilpatrick, and
A Lees, and
C D Marsden
April 1989,
Sheng li ke xue jin zhan [Progress in physiology],
P Jenner, and
N M Rupniak, and
S Rose, and
E Kelly, and
G Kilpatrick, and
A Lees, and
C D Marsden
June 1998,
Parkinsonism & related disorders,
P Jenner, and
N M Rupniak, and
S Rose, and
E Kelly, and
G Kilpatrick, and
A Lees, and
C D Marsden
January 1991,
Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952),
P Jenner, and
N M Rupniak, and
S Rose, and
E Kelly, and
G Kilpatrick, and
A Lees, and
C D Marsden
July 1987,
Journal of neurochemistry,
P Jenner, and
N M Rupniak, and
S Rose, and
E Kelly, and
G Kilpatrick, and
A Lees, and
C D Marsden
January 2003,
Neuroscience,
P Jenner, and
N M Rupniak, and
S Rose, and
E Kelly, and
G Kilpatrick, and
A Lees, and
C D Marsden
June 2006,
The European journal of neuroscience,
P Jenner, and
N M Rupniak, and
S Rose, and
E Kelly, and
G Kilpatrick, and
A Lees, and
C D Marsden
June 1998,
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology,
