BIOMAT Database Logo BIOMAT Database Logo

Comparison of lactate and glucose metabolism in the developing porcine placenta. 1984

T G Ramsay, and J A Sheahan, and R J Martin

The present experiment was conducted to determine whether lactate is an important metabolic substrate for the developing porcine placenta. Pregnant gilts were anesthetized with pentobarbital sodium (5 mg/kg) at 65, 85, or 110 days of gestation and underwent an abdominohysterectomy. Fetal and maternal placental tissues were obtained and isolated for enzyme analysis and tissue incubations. Tissues were incubated for 2 h in Krebs-Ringer bicarbonate buffer containing 10 mM glucose, 1.0 mM Na-palmitate, 2.0 mM L-lactate, and 2% albumin. The incorporation of glucose or lactate into CO2, total lipids, and fatty acids was examined by radioactive tracers. Lactate was shown to be at least as important a substrate as glucose for utilization through these metabolic pathways in both the fetal and maternal placentas during gestation. This ability to metabolize lactate may serve as a conservation mechanism to spare other nutrients for transfer to the fetus. Additionally, analysis of enzyme and incubation data indicated that the fetal and maternal placenta follow different developmental patterns, implying the origins for (or mechanisms of) regulation of these two tissues may differ.

UI MeSH Term Description Entries
D007773 Lactates Salts or esters of LACTIC ACID containing the general formula CH3CHOHCOOR.
D008431 Maternal-Fetal Exchange Exchange of substances between the maternal blood and the fetal blood at the PLACENTA via PLACENTAL CIRCULATION. The placental barrier excludes microbial or viral transmission. Transplacental Exposure,Exchange, Maternal-Fetal,Exposure, Transplacental,Maternal Fetal Exchange
D010084 Oxidation-Reduction A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471). Redox,Oxidation Reduction
D010920 Placenta A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES). Placentoma, Normal,Placentome,Placentas,Placentomes
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D002245 Carbon Dioxide A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals. Carbonic Anhydride,Anhydride, Carbonic,Dioxide, Carbon
D005227 Fatty Acids Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed) Aliphatic Acid,Esterified Fatty Acid,Fatty Acid,Fatty Acids, Esterified,Fatty Acids, Saturated,Saturated Fatty Acid,Aliphatic Acids,Acid, Aliphatic,Acid, Esterified Fatty,Acid, Saturated Fatty,Esterified Fatty Acids,Fatty Acid, Esterified,Fatty Acid, Saturated,Saturated Fatty Acids
D005260 Female Females
D005333 Fetus The unborn young of a viviparous mammal, in the postembryonic period, after the major structures have been outlined. In humans, the unborn young from the end of the eighth week after CONCEPTION until BIRTH, as distinguished from the earlier EMBRYO, MAMMALIAN. Fetal Structures,Fetal Tissue,Fetuses,Mummified Fetus,Retained Fetus,Fetal Structure,Fetal Tissues,Fetus, Mummified,Fetus, Retained,Structure, Fetal,Structures, Fetal,Tissue, Fetal,Tissues, Fetal
D005947 Glucose A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement. Dextrose,Anhydrous Dextrose,D-Glucose,Glucose Monohydrate,Glucose, (DL)-Isomer,Glucose, (alpha-D)-Isomer,Glucose, (beta-D)-Isomer,D Glucose,Dextrose, Anhydrous,Monohydrate, Glucose

Related Publications

T G Ramsay, and J A Sheahan, and R J Martin
Glucose metabolism, lactate, and ammonia production by the human placenta in vitro.
February 1979, Pediatric research,
T G Ramsay, and J A Sheahan, and R J Martin
Effects of lactate on glucose metabolism of developing rat brain.
May 1984, Brain research,
T G Ramsay, and J A Sheahan, and R J Martin
Glutamine synthesis in the developing porcine placenta.
May 2004, Biology of reproduction,
T G Ramsay, and J A Sheahan, and R J Martin
Metabolism of the human placenta perfused in vitro: glucose transfer and utilization, O2 consumption, lactate and ammonia production.
September 1983, Pediatric research,
T G Ramsay, and J A Sheahan, and R J Martin
Polyamine synthesis from proline in the developing porcine placenta.
April 2005, Biology of reproduction,
T G Ramsay, and J A Sheahan, and R J Martin
Fatty acid metabolism by the porcine placenta.
September 1991, Journal of animal science,
T G Ramsay, and J A Sheahan, and R J Martin
[Metabolism during extracorporeal circulation--comparison of glucose, xylitol and Ringer-lactate solution].
July 1969, Kyobu geka. The Japanese journal of thoracic surgery,
T G Ramsay, and J A Sheahan, and R J Martin
[METABOLISM OF GLUCOSE AND FRUCTOSE IN THE HUMAN PLACENTA].
November 1963, Rivista di ostetricia e ginecologia,
T G Ramsay, and J A Sheahan, and R J Martin
Comparison of the effects of dietary glucose versus galactose on porcine feto-placental glucose metabolism.
October 1990, The Journal of nutrition,
T G Ramsay, and J A Sheahan, and R J Martin
Modeling glucose metabolism and lactate production in the kidney.
July 2017, Mathematical biosciences,
Copied contents to your clipboard!