BIOMAT Database Logo BIOMAT Database Logo

Gonadotrophin responses to GnRH in precocious puberty treated with GnRH analogue. 1984

M D Donaldson, and R Stanhope, and T J Lee, and D A Price, and C G Brook, and D C Savage

The gonadotrophin releasing hormone analogue Buserelin was given by intranasal spray to 13 children with precocious puberty. The LH responses to GnRH reverted to prepubertal levels in the boys on 200-400 micrograms daily of the analogue while doses of 400-1200 micrograms daily were needed to suppress the girls. The significance of this apparent sex difference is uncertain.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D007986 Luteinizing Hormone A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity. ICSH (Interstitial Cell Stimulating Hormone),Interstitial Cell-Stimulating Hormone,LH (Luteinizing Hormone),Lutropin,Luteoziman,Luteozyman,Hormone, Interstitial Cell-Stimulating,Hormone, Luteinizing,Interstitial Cell Stimulating Hormone
D008297 Male Males
D010906 Pituitary Hormone-Releasing Hormones Peptides, natural or synthetic, that stimulate the release of PITUITARY HORMONES. They were first isolated from the extracts of the HYPOTHALAMUS; MEDIAN EMINENCE; PITUITARY STALK; and NEUROHYPOPHYSIS. In addition, some hypophysiotropic hormones control pituitary cell differentiation, cell proliferation, and hormone synthesis. Some can act on more than one pituitary hormone. Hormones, Pituitary Hormone Releasing,Hypophysiotropic Hormones,Hypothalamic Hypophysiotropic Hormone,Hypothalamic Releasing Factor,Hypothalamic Releasing Hormone,Hypothalamic Releasing Hormones,Hormone, Hypothalamic Hypophysiotropic,Hormones, Hypophysiotropic,Hypophysiotropic Hormone, Hypothalamic,Pituitary Hormone Releasing Hormones,Releasing Hormone, Hypothalamic
D011629 Puberty, Precocious Development of SEXUAL MATURATION in boys and girls at a chronological age that is 2.5 standard deviations below the mean age at onset of PUBERTY in the population. This early maturation of the hypothalamic-pituitary-gonadal axis results in sexual precocity, elevated serum levels of GONADOTROPINS and GONADAL STEROID HORMONES such as ESTRADIOL and TESTOSTERONE. Familial Precocious Puberty,Idiopathic Sexual Precocity,Precocious Puberty,Precocious Puberty, Central,Precocious Puberty, Male Limited,Precocious Puberty, Male-Limited,Pubertas Praecox,Sexual Precocity,Testotoxicosis,Central Precocious Puberties,Central Precocious Puberty,Familial Precocious Puberties,Idiopathic Sexual Precocities,Male-Limited Precocious Puberties,Male-Limited Precocious Puberty,Praecox, Pubertas,Precocious Puberties,Precocious Puberties, Central,Precocious Puberties, Familial,Precocious Puberties, Male-Limited,Precocious Puberty, Familial,Precocities, Idiopathic Sexual,Precocities, Sexual,Precocity, Idiopathic Sexual,Precocity, Sexual,Puberties, Central Precocious,Puberties, Familial Precocious,Puberties, Male-Limited Precocious,Puberties, Precocious,Puberty, Central Precocious,Puberty, Familial Precocious,Puberty, Male-Limited Precocious,Sexual Precocities,Sexual Precocities, Idiopathic,Sexual Precocity, Idiopathic
D002064 Buserelin A potent synthetic analog of GONADOTROPIN-RELEASING HORMONE with D-serine substitution at residue 6, glycine10 deletion, and other modifications. Bigonist,Buserelin Acetate,HOE-766,Profact,Receptal,Suprecur,Suprefact,Tiloryth,Acetate, Buserelin,HOE 766,HOE766
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D003864 Depression, Chemical The decrease in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical. Chemical Depression,Chemical Depressions,Depressions, Chemical
D005260 Female Females

Related Publications

M D Donaldson, and R Stanhope, and T J Lee, and D A Price, and C G Brook, and D C Savage
Growth, growth hormone and sex steroid secretion in girls with central precocious puberty treated with a gonadotrophin releasing hormone (GnRH) analogue.
July 1988, Acta paediatrica Scandinavica,
M D Donaldson, and R Stanhope, and T J Lee, and D A Price, and C G Brook, and D C Savage
Leptin concentrations in precocious puberty or untimely puberty with and without GnRH analogue therapy.
January 1999, Journal of pediatric endocrinology & metabolism : JPEM,
M D Donaldson, and R Stanhope, and T J Lee, and D A Price, and C G Brook, and D C Savage
Successful treatment of hypothalamic seizures and precocious puberty with GnRH analogue.
December 2000, Neurology,
M D Donaldson, and R Stanhope, and T J Lee, and D A Price, and C G Brook, and D C Savage
Clinical suppression of precocious puberty with cetrorelix after failed treatment with GnRH agonist in a girl with gonadotrophin-independent precocious puberty.
July 2005, Reproductive biomedicine online,
M D Donaldson, and R Stanhope, and T J Lee, and D A Price, and C G Brook, and D C Savage
Hormonal changes during GnRH analogue therapy in children with central precocious puberty.
July 2000, Journal of pediatric endocrinology & metabolism : JPEM,
M D Donaldson, and R Stanhope, and T J Lee, and D A Price, and C G Brook, and D C Savage
Blood pressure in girls with central precocious puberty receiving GnRH analogue therapy.
August 2023, Journal of pediatric endocrinology & metabolism : JPEM,
M D Donaldson, and R Stanhope, and T J Lee, and D A Price, and C G Brook, and D C Savage
Assessment of gonadotrophin suppression in girls treated with GnRH analogue for central precocious puberty; validity of single luteinizing hormone measurement after leuprolide acetate injection.
January 2012, Clinical endocrinology,
M D Donaldson, and R Stanhope, and T J Lee, and D A Price, and C G Brook, and D C Savage
Initial growth deceleration during GnRH analogue therapy for precocious puberty.
May 2009, Clinical endocrinology,
M D Donaldson, and R Stanhope, and T J Lee, and D A Price, and C G Brook, and D C Savage
Long-acting GnRH analogue triptorelin therapy in central isosexual precocious puberty.
July 2002, Indian pediatrics,
M D Donaldson, and R Stanhope, and T J Lee, and D A Price, and C G Brook, and D C Savage
Reversible inhibition of central precocious puberty with a long acting GnRH analogue.
January 1986, Archives of disease in childhood,
Copied contents to your clipboard!