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The regulation of TSH and GH secretion was investigated in cultured tumor cells prepared from a mixed TSH/GH secreting pituitary tumor. The tumor tissue had been removed transsphenoidally from a patient with hyperthyroidism and inappropriately high serum TSH levels and acromegaly. TSH and GH secretion by cultured cells were stimulated in a parallel way by TRH (300 nM) and LHRH (50 nM), but were unaffected by bromocriptine (10 nM). Exposure of the tumor cells to dexamethasone (0.1 microM) or T3 (50 nM) had differential effects on hormone secretion. GH secretion was greatly stimulated by dexamethasone, but unaffected by T3. TSH secretion was inhibited both by T3 and by dexamethasone. So, T3 and glucocorticoids inhibit TSH release by the human pituitary tumor cells studied at least partly by means of a direct effect.
S W Lamberts, and
R Oosterom, and
T Verleun, and
E P Krenning, and
H Assies
January 1981,
Progress in clinical and biological research,
S W Lamberts, and
R Oosterom, and
T Verleun, and
E P Krenning, and
H Assies
March 1989,
Journal of neurochemistry,
S W Lamberts, and
R Oosterom, and
T Verleun, and
E P Krenning, and
H Assies
October 1974,
Molecular and cellular endocrinology,
S W Lamberts, and
R Oosterom, and
T Verleun, and
E P Krenning, and
H Assies
July 1984,
Endocrinology,
S W Lamberts, and
R Oosterom, and
T Verleun, and
E P Krenning, and
H Assies
January 1992,
European journal of cancer (Oxford, England : 1990),
S W Lamberts, and
R Oosterom, and
T Verleun, and
E P Krenning, and
H Assies
November 1977,
Science (New York, N.Y.),
S W Lamberts, and
R Oosterom, and
T Verleun, and
E P Krenning, and
H Assies
January 1985,
Journal of molecular biology,
S W Lamberts, and
R Oosterom, and
T Verleun, and
E P Krenning, and
H Assies
January 1988,
Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie,
S W Lamberts, and
R Oosterom, and
T Verleun, and
E P Krenning, and
H Assies
January 1981,
Endocrinology,
S W Lamberts, and
R Oosterom, and
T Verleun, and
E P Krenning, and
H Assies
August 1989,
Endocrinology,
