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Total bilirubin formation (TBF) in the rat after a short period of common bile duct ligation was studied by measuring the pulmonary excretion rate of CO (VECO). At postoperative day 3, the VECO of experimental animals was higher when compared with the preoperative VECO (p less than 0.005); whereas the VECO of control animals did not change. Also, on the 3rd postoperative day, the relative rate of early labeling of bilirubin following the administration of delta-aminolevulinic acid-5-14C, a preferential hepatic heme synthesis precursor, was similar between the experimental and control animals; only the experimental animals had an abnormal peroxide hemolysis test. We conclude that common bile duct ligation in the rat is associated with elevations in the VECO, indicating significant increases in TBF, and the source of the increase is probably of erythropoietic origin. This finding may be relevant to the understanding of the pathophysiology of obstructive jaundice in human neonates.
D K Stevenson, and
W L Salomon, and
L Y Moore, and
J K Trudgen, and
B E Cowan, and
H J Vreman, and
L K Kwong
January 1987,
Journal of pediatric gastroenterology and nutrition,
D K Stevenson, and
W L Salomon, and
L Y Moore, and
J K Trudgen, and
B E Cowan, and
H J Vreman, and
L K Kwong
October 1979,
The Journal of laboratory and clinical medicine,
D K Stevenson, and
W L Salomon, and
L Y Moore, and
J K Trudgen, and
B E Cowan, and
H J Vreman, and
L K Kwong
January 1989,
Journal of medical primatology,
D K Stevenson, and
W L Salomon, and
L Y Moore, and
J K Trudgen, and
B E Cowan, and
H J Vreman, and
L K Kwong
January 1997,
Journal of the Formosan Medical Association = Taiwan yi zhi,
D K Stevenson, and
W L Salomon, and
L Y Moore, and
J K Trudgen, and
B E Cowan, and
H J Vreman, and
L K Kwong
February 2005,
Journal of applied physiology (Bethesda, Md. : 1985),
D K Stevenson, and
W L Salomon, and
L Y Moore, and
J K Trudgen, and
B E Cowan, and
H J Vreman, and
L K Kwong
January 2015,
Magnesium research,
D K Stevenson, and
W L Salomon, and
L Y Moore, and
J K Trudgen, and
B E Cowan, and
H J Vreman, and
L K Kwong
July 2001,
Journal of gastroenterology and hepatology,
D K Stevenson, and
W L Salomon, and
L Y Moore, and
J K Trudgen, and
B E Cowan, and
H J Vreman, and
L K Kwong
June 1979,
The Journal of pediatrics,
D K Stevenson, and
W L Salomon, and
L Y Moore, and
J K Trudgen, and
B E Cowan, and
H J Vreman, and
L K Kwong
November 1979,
Pediatrics,
D K Stevenson, and
W L Salomon, and
L Y Moore, and
J K Trudgen, and
B E Cowan, and
H J Vreman, and
L K Kwong
October 1988,
Research communications in chemical pathology and pharmacology,
