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Using indomethacin (Ind), a prostaglandin synthesis inhibitor, in vivo experiments in rats and in vitro experiments with perifusion systems of rat thyroids and pituitaries were conducted. After 35 days of intragastric infusion of Ind, serum TSH levels were markedly increased, the thyroid was swollen and, as a consequence, T3 and T4 levels were normal. The T3 release from perifused rat thyroids under continuous stimulation with 10 mU/ml TSH was inhibited significantly (p less than 0.01) by 1.0 X 10(-6) M Ind. On the other hand, the TSH release from perifused rat pituitaries under TRH stimulation was enhanced conspicuously by Ind. It was concluded that Ind decelerated thyroid hormone release from the thyroid and accelerated TSH release from the pituitary in perifusion systems.
K Mashita, and
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S Kawamura, and
S Tarui
August 1979,
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K Mashita, and
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S Tarui
May 1981,
The American journal of physiology,
K Mashita, and
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February 1976,
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K Mashita, and
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September 1973,
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K Mashita, and
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Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
K Mashita, and
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December 1986,
Endocrinology,
K Mashita, and
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June 1969,
Endocrinology,
K Mashita, and
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May 1977,
Journal of reproduction and fertility,
K Mashita, and
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March 1992,
Neuroscience letters,
K Mashita, and
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December 1992,
Endocrine regulations,
