Biomaterial Database

Metabolism of 7,12-dimethylbenz(a)anthracene by alveolar macrophages containing ingested ferric oxide, aluminum oxide or carbon particles. 1984

W G Palmer, and D A Creasia

Rat alveolar macrophages with ingested aluminum oxide (Al2O3), ferric oxide (Fe2O3) or carbon particles were incubated for 24 hours with 3H-7, 12-dimethylbenz(a)anthracene (DMBA). Essentially the same amounts and types of metabolites were produced by and released from macrophages with ingested Fe2O3 and Al2O3 particles. Smaller quantities of DMBA and its metabolites could be extracted with ethyl acetate from the culture media and cell lysates of macrophages with ingested carbon particles than from those with Fe2O3 and Al2O3 particles. Also, more of the intracellular radioactivity was associated with insoluble material in macrophages with ingested carbon than in those with the other two types of particles. The results suggest that the inability of Al2O3 to act as a co-carcinogenic carrier for polycyclic aromatic hydrocarbons (PAH) is not related to its effect on PAH metabolism. However, adsorption of PAH and their nonpolar metabolites to carbon may alter the exposure pattern of pulmonary tissues to PAH and their metabolites.

UI	MeSH Term	Description	Entries
D007501	Iron	A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.	Iron-56,Iron 56
D008264	Macrophages	The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)	Bone Marrow-Derived Macrophages,Monocyte-Derived Macrophages,Macrophage,Macrophages, Monocyte-Derived,Bone Marrow Derived Macrophages,Bone Marrow-Derived Macrophage,Macrophage, Bone Marrow-Derived,Macrophage, Monocyte-Derived,Macrophages, Bone Marrow-Derived,Macrophages, Monocyte Derived,Monocyte Derived Macrophages,Monocyte-Derived Macrophage
D008297	Male		Males
D008657	Metabolic Clearance Rate	Volume of biological fluid completely cleared of drug metabolites as measured in unit time. Elimination occurs as a result of metabolic processes in the kidney, liver, saliva, sweat, intestine, heart, brain, or other site.	Total Body Clearance Rate,Clearance Rate, Metabolic,Clearance Rates, Metabolic,Metabolic Clearance Rates,Rate, Metabolic Clearance,Rates, Metabolic Clearance
D010316	Particle Size	Relating to the size of solids.	Particle Sizes,Size, Particle,Sizes, Particle
D011650	Pulmonary Alveoli	Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.	Alveoli, Pulmonary,Alveolus, Pulmonary,Pulmonary Alveolus
D002244	Carbon	A nonmetallic element with atomic symbol C, atomic number 6, and atomic weight [12.0096; 12.0116]. It may occur as several different allotropes including DIAMOND; CHARCOAL; and GRAPHITE; and as SOOT from incompletely burned fuel.	Carbon-12,Vitreous Carbon,Carbon 12,Carbon, Vitreous
D005290	Ferric Compounds	Inorganic or organic compounds containing trivalent iron.	Compounds, Ferric
D000535	Aluminum	A metallic element that has the atomic number 13, atomic symbol Al, and atomic weight 26.98.	Aluminium,Aluminium-27,Aluminum-27,Aluminium 27,Aluminum 27
D000537	Aluminum Oxide	An oxide of aluminum, occurring in nature as various minerals such as bauxite, corundum, etc. It is used as an adsorbent, desiccating agent, and catalyst, and in the manufacture of dental cements and refractories.	Alumina,Alumina Ceramic,Aluminum Oxide (Al130O40),Aluminum Oxide (Al2O),Aluminum Oxide (AlO2),Bauxite,Corundum,Sapphire,Ceramic, Alumina,Oxide, Aluminum