-transparent.png){kind=logo}
The purpose of this study was to test in double-blind trial the tolerance and antihypertensive effect of nicardipine versus placebo in 32 elderly patients (mean age: 84 years). Nicardipine was given three times a day (mean dose: 69.4 mg per day). After four weeks, nicardipine lowered blood pressure (BP) from 186 +/- 4 mmHg/99.5 +/- 3 mmHg to 150 +/- 6/84 +/- 3 mmHg (p less than 0.001). 10 out of 16 patients were normalized (BP less than 160-95 mmHg). The placebo group remained hypertensive: 181 +/- 7/96 +/- 4 mmHg versus 183 +/- 4/101 +/- 3 mmHg (NS). 3 placebo treated patients were nevertheless normalized. The changes in systolic BP and diastolic BP were significantly greater in the Nicardipine group: respectively -36 +/- 4 versus -2 +/- 6 mmHg (p less than 0.001), -16 +/- 3 versus -5 +/- 4 mmHg (p less than 0.05). Treatment was very well tolerated. Orthostatic hypotension, change in heart rate, variation in biological parameters were never observed. These data agree with Buhler's statement suggesting that calcium channel inhibitors can represent an interesting alternative to diuretics as first line monotherapy in the treatment of hypertension in the elderly.
F Forette, and
M Bellet, and
J F Henry, and
M P Hervy, and
C Poyard-Salmeron, and
P Bouchacourt
May 1987,
Cardiologia (Rome, Italy),
F Forette, and
M Bellet, and
J F Henry, and
M P Hervy, and
C Poyard-Salmeron, and
P Bouchacourt
July 1987,
Cardiologia (Rome, Italy),
F Forette, and
M Bellet, and
J F Henry, and
M P Hervy, and
C Poyard-Salmeron, and
P Bouchacourt
May 1985,
Bollettino chimico farmaceutico,
F Forette, and
M Bellet, and
J F Henry, and
M P Hervy, and
C Poyard-Salmeron, and
P Bouchacourt
January 1991,
Sovetskaia meditsina,
F Forette, and
M Bellet, and
J F Henry, and
M P Hervy, and
C Poyard-Salmeron, and
P Bouchacourt
January 1987,
Ugeskrift for laeger,
F Forette, and
M Bellet, and
J F Henry, and
M P Hervy, and
C Poyard-Salmeron, and
P Bouchacourt
June 1999,
The Journal of thoracic and cardiovascular surgery,
F Forette, and
M Bellet, and
J F Henry, and
M P Hervy, and
C Poyard-Salmeron, and
P Bouchacourt
November 1989,
Drug and therapeutics bulletin,
F Forette, and
M Bellet, and
J F Henry, and
M P Hervy, and
C Poyard-Salmeron, and
P Bouchacourt
December 1983,
Schweizerische medizinische Wochenschrift,
F Forette, and
M Bellet, and
J F Henry, and
M P Hervy, and
C Poyard-Salmeron, and
P Bouchacourt
June 1989,
Journal of clinical pharmacology,
F Forette, and
M Bellet, and
J F Henry, and
M P Hervy, and
C Poyard-Salmeron, and
P Bouchacourt
April 1997,
Journal of cardiothoracic and vascular anesthesia,
