BIOMAT Database Logo BIOMAT Database Logo

Species differences in levonorgestrel binding to serum proteins of monkey, rabbit and rat blood. 1984

A K Srivastava, and G Chandra, and S K Roy

Levonorgestrel binding to serum proteins of monkey, rabbit and rat was studied. It showed high affinity binding to monkey and rabbit serum proteins but not to rat serum. Characterization by polyacrylamide gel electrophoresis revealed that the binding of levonorgestrel occurs to sex hormone binding globulin (SHBG) and albumin, but in rat it is confined to albumin only. These results suggest species differences in levonorgestrel binding to serum proteins and extrapolation of data from one animal model to another may not be directly feasible.

UI MeSH Term Description Entries
D008253 Macaca mulatta A species of the genus MACACA inhabiting India, China, and other parts of Asia. The species is used extensively in biomedical research and adapts very well to living with humans. Chinese Rhesus Macaques,Macaca mulatta lasiota,Monkey, Rhesus,Rhesus Monkey,Rhesus Macaque,Chinese Rhesus Macaque,Macaca mulatta lasiotas,Macaque, Rhesus,Rhesus Macaque, Chinese,Rhesus Macaques,Rhesus Macaques, Chinese,Rhesus Monkeys
D009644 Norgestrel A synthetic progestational agent with actions similar to those of PROGESTERONE. This racemic or (+-)-form has about half the potency of the levo form (LEVONORGESTREL). Norgestrel is used as a contraceptive, ovulation inhibitor, and for the control of menstrual disorders and endometriosis. 18,19-Dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, (17alpha)-(+-)-,DL-Norgestrel,Neogest,Ovrette,Postinor,Wy-3707,DL Norgestrel,Wy 3707,Wy3707
D011817 Rabbits A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes. Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D001798 Blood Proteins Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins. Blood Protein,Plasma Protein,Plasma Proteins,Serum Protein,Serum Proteins,Protein, Blood,Protein, Plasma,Protein, Serum,Proteins, Blood,Proteins, Plasma,Proteins, Serum
D003277 Contraceptives, Oral, Combined Fixed drug combinations administered orally for contraceptive purposes. Combined Oral Contraceptive,Contraceptive Agents, Female, Combined,Oral Contraceptives, Combined,Combined Oral Contraceptives,Contraceptive, Combined Oral,Contraceptives, Combined Oral,Oral Contraceptive, Combined
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001667 Binding, Competitive The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements. Competitive Binding
D013045 Species Specificity The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species. Species Specificities,Specificities, Species,Specificity, Species
D014316 Tritium The radioactive isotope of hydrogen also known as hydrogen-3. It contains two NEUTRONS and one PROTON in its nucleus and decays to produce low energy BETA PARTICLES. Hydrogen-3,Hydrogen 3

Related Publications

A K Srivastava, and G Chandra, and S K Roy
Binding of levonorgestrel to monkey plasma proteins.
February 1983, Experientia,
A K Srivastava, and G Chandra, and S K Roy
Serum protein binding characteristics of cyproterone acetate, gestodene, levonorgestrel and norethisterone in rat, rabbit, dog, monkey and man.
February 1990, Journal of steroid biochemistry,
A K Srivastava, and G Chandra, and S K Roy
Uric acid binding to serum proteins: differences among species.
February 1972, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
A K Srivastava, and G Chandra, and S K Roy
[Binding of sulfamethoxydine on blood proteins in relation to age. Comparison of binding to human serum proteins with binding to rat serum proteins].
January 1976, Ceskoslovenska fysiologie,
A K Srivastava, and G Chandra, and S K Roy
The thyroxine-binding properties of rat and rabbit serum proteins.
January 1976, Endocrinology,
A K Srivastava, and G Chandra, and S K Roy
Structural differences among serum IgA proteins of chimpanzee, rhesus monkey and rat origin.
May 1997, Molecular immunology,
A K Srivastava, and G Chandra, and S K Roy
Gender-related differences of serum thyroxine-binding proteins in the rat.
July 1990, Acta endocrinologica,
A K Srivastava, and G Chandra, and S K Roy
[Neomycin binding to blood serum proteins].
January 1969, Voprosy meditsinskoi khimii,
A K Srivastava, and G Chandra, and S K Roy
Binding of the gestagens norethisterone and levonorgestrel in blood of various species.
October 1981, Journal of steroid biochemistry,
A K Srivastava, and G Chandra, and S K Roy
Vitamin B12 binding proteins in monkey serum and red cells.
December 1973, Biochimica et biophysica acta,
Copied contents to your clipboard!