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The pharmacological investigation of the ergot alkaloid of the group of clavines elymoclavine isolated from Claviceps sp. cp. II showed the following: LD50 for mice for 24 hours was 350 (228 divided by 535) mg/kg and for rats--145 (81 divided by 258) mg/kg; elymoclavine induced a dose-dependent stereotypy in rats and mice which was antagonized by haloperidol and pimozide; it prevented the development of haloperidol catalepsy in rats and produced rotations contralateral to the striatal lesions with 6-OHDA which were antagonized by pimozide and partly by cyproheptadine. Elymoclavine increased the exploratory activity of rats in open field as this effect was antagonized by haloperidol and was essentially influenced by many substances acting on different transmitter systems (NA, DA, GABA). Elymoclavine inhibited the picroroxin and electroshock convulsive seizures but potentiated the pentylenetetrazol ones in mice as these effects were differently influenced by pimozide, haloperidol, 5-HT, atropine and phentolamine. The observed effects of elymoclavine are mainly due to its DAergic agonistic action. It seems, however, that influences on other transmitter receptors also underlie the mechanism of action of this ergot alkaloid.
K Roussinov, and
V Georgiev, and
V Petkov, and
M Lazarova, and
B Petkova, and
S Shopova, and
V Markovska, and
D Getova, and
S Draganova
January 1987,
Zentralblatt fur Mikrobiologie,
K Roussinov, and
V Georgiev, and
V Petkov, and
M Lazarova, and
B Petkova, and
S Shopova, and
V Markovska, and
D Getova, and
S Draganova
April 1967,
Archives internationales de pharmacodynamie et de therapie,
K Roussinov, and
V Georgiev, and
V Petkov, and
M Lazarova, and
B Petkova, and
S Shopova, and
V Markovska, and
D Getova, and
S Draganova
December 1975,
Journal of animal science,
K Roussinov, and
V Georgiev, and
V Petkov, and
M Lazarova, and
B Petkova, and
S Shopova, and
V Markovska, and
D Getova, and
S Draganova
August 1984,
Methods and findings in experimental and clinical pharmacology,
K Roussinov, and
V Georgiev, and
V Petkov, and
M Lazarova, and
B Petkova, and
S Shopova, and
V Markovska, and
D Getova, and
S Draganova
January 2005,
Journal of rehabilitation research and development,
K Roussinov, and
V Georgiev, and
V Petkov, and
M Lazarova, and
B Petkova, and
S Shopova, and
V Markovska, and
D Getova, and
S Draganova
July 2002,
Pharmacological research,
K Roussinov, and
V Georgiev, and
V Petkov, and
M Lazarova, and
B Petkova, and
S Shopova, and
V Markovska, and
D Getova, and
S Draganova
August 1965,
The Journal of pharmacy and pharmacology,
K Roussinov, and
V Georgiev, and
V Petkov, and
M Lazarova, and
B Petkova, and
S Shopova, and
V Markovska, and
D Getova, and
S Draganova
January 1963,
Occupational health review,
K Roussinov, and
V Georgiev, and
V Petkov, and
M Lazarova, and
B Petkova, and
S Shopova, and
V Markovska, and
D Getova, and
S Draganova
June 1979,
The Indian journal of medical research,
K Roussinov, and
V Georgiev, and
V Petkov, and
M Lazarova, and
B Petkova, and
S Shopova, and
V Markovska, and
D Getova, and
S Draganova
August 1965,
Planta medica,
