-transparent.png){kind=logo}
Fifty children with IgA deficiency were folllowed for 1 to 4 years from 1975 to 1978. Thirty-five had complete deficiency of serum IgA (less than 2.5 IU/ml) and 15 partial deficiency (serum IgA below the 10th centile for age). Patients with another associated immunodeficiency, such as ataxia-telangiectasia, were not included. Most children with complete deficiency of IgA had recurrent respiratory and/or gastrointestinal infections, about half with onset in the first year of life, while partial deficiency of IgA has probably little if any importance for anti-infectious immunity but is important in the pathogenesis of atopy. Atopic diseases were frequent in both groups. Chromosomal abnormalities were found in 2 patients: trisomy 21 in one and in the other a ring chromosome 18. No important defects in cellular immunity were detected but some isolated, borderline abnormalities were often present.
G R Burgio, and
M Duse, and
V Monafo, and
A Ascione, and
L Nespoli
January 1989,
The Turkish journal of pediatrics,
G R Burgio, and
M Duse, and
V Monafo, and
A Ascione, and
L Nespoli
April 1992,
Tijdschrift voor kindergeneeskunde,
G R Burgio, and
M Duse, and
V Monafo, and
A Ascione, and
L Nespoli
June 1986,
Clinical and experimental immunology,
G R Burgio, and
M Duse, and
V Monafo, and
A Ascione, and
L Nespoli
January 2009,
Journal of clinical immunology,
G R Burgio, and
M Duse, and
V Monafo, and
A Ascione, and
L Nespoli
January 1981,
Terapevticheskii arkhiv,
G R Burgio, and
M Duse, and
V Monafo, and
A Ascione, and
L Nespoli
January 1975,
Birth defects original article series,
G R Burgio, and
M Duse, and
V Monafo, and
A Ascione, and
L Nespoli
December 2019,
Journal of translational autoimmunity,
G R Burgio, and
M Duse, and
V Monafo, and
A Ascione, and
L Nespoli
December 1973,
Australian and New Zealand journal of medicine,
G R Burgio, and
M Duse, and
V Monafo, and
A Ascione, and
L Nespoli
January 1990,
Allergologia et immunopathologia,
G R Burgio, and
M Duse, and
V Monafo, and
A Ascione, and
L Nespoli
June 1980,
Clinical and experimental immunology,
