Experimental studies were attempted for electrophoretic and phonophoretic application of propolis. Gross, histomorphologic and histochemical investigation clearly demonstrated that propolis may readily be introduced by phono- and electrophoresis in the tissues of experimental animals at the site of application. No polarity difference was recorded on electrophoretic application, which seems to be due to the complex nature of propolis. It is recommended to apply electrophoretically propolis on both poles. Histochemical investigation demonstrated that more effective is the phonophoretic method of introduction of propolis. Phonophoresis with propolis ointment caused decrease in skin sensitivity, attributable to the anesthetizing effect on the skin receptors.