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Moxalactam (LY127935) exhibited greater in vitro activity than cefamandole and tobramycin against clinical isolates of Enterobacteriaceae, Aeromonas hydrophila, and Pseudomonas maltophilia. The activities of the three drugs against other microorganisms were as follows: for staphylococci, cefamandole = tobramycin greater than moxalactam; for streptococci, cefamandole greater than moxalactam greater than tobramycin; and for Pseudomonas aeruginosa, tobramycin greater than moxalactam greater than cefamandole. Moxalactam also demonstrated significant activity against the Bacteroides fragilis group and other anaerobes. Moxalactam was comparable to cefotaxime (HR756) in its inhibition of cephalothin-resistant and aminoglycoside-resistant clinical isolates.
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R N Jones, and
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July 1980,
The Journal of antimicrobial chemotherapy,
R N Jones, and
P C Fuchs, and
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T L Gavan, and
A L Barry, and
E H Gerlach
February 1980,
Antimicrobial agents and chemotherapy,
R N Jones, and
P C Fuchs, and
H M Sommers, and
T L Gavan, and
A L Barry, and
E H Gerlach
February 1980,
Antimicrobial agents and chemotherapy,
R N Jones, and
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E H Gerlach
April 1984,
Chemioterapia : international journal of the Mediterranean Society of Chemotherapy,
R N Jones, and
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H M Sommers, and
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E H Gerlach
September 1981,
Zhonghua Minguo wei sheng wu ji mian yi xue za zhi = Chinese journal of microbiology and immunology,
R N Jones, and
P C Fuchs, and
H M Sommers, and
T L Gavan, and
A L Barry, and
E H Gerlach
November 1981,
Antimicrobial agents and chemotherapy,
