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Thyrotoxicosis in rabbits was induced by prolonged intraperitoneal injection of L-thyroxin. The development of thyroxicosis was assoiated with a decreased Ca2+ accumulation rate by sarcoplasmic reticulum (SR) fragments and a lowered Ca2+ dependent ATPase activity. As compared to the analogous parameters in normal animals. Ca2+ accumulation rate and ATPase activity of thyrotoxicosis animals decreased by 60 and 25%, respectively. The changes in the specific parameters of SR were also observed during incubation of normal SR samples in the medium containing thyroxin (10-5 M). The changes seen in SR functioning in thyrotoxicosis animals are likely to be related to structural rearrangements of lipoprotein surroundings of Ca-ATPase.
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Iu A Vladimirov
April 1980,
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A I Marzoev, and
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December 1972,
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A I Marzoev, and
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June 1992,
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A I Marzoev, and
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September 1979,
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A I Marzoev, and
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A I Marzoev, and
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July 1971,
Biochemistry,
A I Marzoev, and
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February 1986,
The Journal of physiology,
A I Marzoev, and
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December 2006,
Neuro endocrinology letters,
A I Marzoev, and
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July 1981,
The Biochemical journal,
A I Marzoev, and
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G I Klebanov, and
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Farmakologiia i toksikologiia,
