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In patients with psoriasis in extra- and intracellular deficiency of dehydroepiandrosterone can be demonstrated which leads to an activation of the pentose-phosphate cycle. This dehydroepiandrosterone deficiency is caused by an increased intracellular activity of 17 beta-hydroxysteroid-dehydrogenase. This results in an increased formation of the reduction product androstendiol, which is unable to inhibit the glucose-6-phosphate dehydrogenase, the keye enzyme of the pentose-phosphate cycle. In addition, a decreased penetration of the steroid through the membrane of erythrocytes is demonstrable, by which the intracellular deficiency of dehydroepiandrosterone is still augmented. The effects of this dehydroepiandrosterone deficiency are changes in the humoral regulation of events in growth and proliferation in patients with psoriasis.
H Holzmann, and
P Benes, and
B Morsches
January 1973,
Actas dermo-sifiliograficas,
H Holzmann, and
P Benes, and
B Morsches
January 1984,
The Annals of otology, rhinology & laryngology. Supplement,
H Holzmann, and
P Benes, and
B Morsches
April 1965,
Il Policlinico. Sezione pratica,
H Holzmann, and
P Benes, and
B Morsches
January 1990,
Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi,
H Holzmann, and
P Benes, and
B Morsches
March 2022,
Experimental and therapeutic medicine,
H Holzmann, and
P Benes, and
B Morsches
October 1950,
L'union medicale du Canada,
H Holzmann, and
P Benes, and
B Morsches
January 1984,
The Annals of otology, rhinology, and laryngology,
H Holzmann, and
P Benes, and
B Morsches
September 1974,
Meditsinskaia sestra,
H Holzmann, and
P Benes, and
B Morsches
April 2014,
Diseases of the colon and rectum,
H Holzmann, and
P Benes, and
B Morsches
December 1964,
The British journal of dermatology,
