The potentialities of laparoscopy, associated with instrumental palpation, intraperitoneal radiometry, aimed puncture biopsy, were assessed in females with genital tumors. Moreover, peritoneal smears obtained by a special sound-brush were assayed histologically. This enabled not only establishing the correct diagnosis (in 96.3% of cases) and the recognition of the tumor microdissemination but also a selection of the optimum therapeutic policy. In 14 patients with the ascites syndrome a laparoscopically guided drainage and infusion therapy with hyperoxygenation were performed. The preliminary results indicate the necessity to further study and elaborate the technic concerned.