-transparent.png){kind=logo}
Murine cytolytic T lymphocytes can be kept in continuous culture apparently indefinitely by repeated passage in a concanavalin A-induced growth promoting medium. Some of these long-term cell lines maintain their cytolytic activity. Starting from three such populations, several cloned cytolytic T cell lines were derived and subsequently subcloned one or more times. Considerable variation in the levels of cytolytic activity was observed between different subclones; some initially active subclones lost activity with prolonged culture. In addition, one of the clones appeared to progressively lose the relative specificity demonstrated during the earlier passages of the parent cell line.
H D Engers, and
D Collavo, and
M North, and
H von Boehmer, and
W Haas, and
H Hengartner, and
M Nabholz
April 1980,
The Journal of experimental medicine,
H D Engers, and
D Collavo, and
M North, and
H von Boehmer, and
W Haas, and
H Hengartner, and
M Nabholz
May 1982,
Journal of immunology (Baltimore, Md. : 1950),
H D Engers, and
D Collavo, and
M North, and
H von Boehmer, and
W Haas, and
H Hengartner, and
M Nabholz
April 1984,
Cancer genetics and cytogenetics,
H D Engers, and
D Collavo, and
M North, and
H von Boehmer, and
W Haas, and
H Hengartner, and
M Nabholz
April 1981,
Journal of immunology (Baltimore, Md. : 1950),
H D Engers, and
D Collavo, and
M North, and
H von Boehmer, and
W Haas, and
H Hengartner, and
M Nabholz
March 1988,
Immunological reviews,
H D Engers, and
D Collavo, and
M North, and
H von Boehmer, and
W Haas, and
H Hengartner, and
M Nabholz
December 1982,
Journal of immunology (Baltimore, Md. : 1950),
H D Engers, and
D Collavo, and
M North, and
H von Boehmer, and
W Haas, and
H Hengartner, and
M Nabholz
July 1981,
Journal of immunology (Baltimore, Md. : 1950),
H D Engers, and
D Collavo, and
M North, and
H von Boehmer, and
W Haas, and
H Hengartner, and
M Nabholz
January 1987,
Nature,
H D Engers, and
D Collavo, and
M North, and
H von Boehmer, and
W Haas, and
H Hengartner, and
M Nabholz
January 1979,
The Journal of experimental medicine,
H D Engers, and
D Collavo, and
M North, and
H von Boehmer, and
W Haas, and
H Hengartner, and
M Nabholz
January 1986,
Current topics in microbiology and immunology,
