-transparent.png){kind=logo}
Dichloromethylene diphosphonate (Cl2MDP, or clodronate disodium) is one of the most potent of the known diphosphonates as an inhibitor of bone resorption and differs from EHDP in that it does not inhibit skeletal mineralization. It is one of the second generation diphosphonates now undergoing clinical evaluation. In the study described here Cl2MDP was given by mouth (800-1600 mg/day for 6 months) to 35 patients with symptomatic Paget's disease of bone. Cl2MDP induced a marked fall in serum alkaline phosphatase and urinary hydroxyproline to normal or near normal values in all patients. This was accompanied by clinical improvement in all but 4 patients. Cl2MDP appears to be another effective oral drug for the treatment of Paget's disease of bone and compares favorably with the calcitonins and EHDP.
D L Douglas, and
T Duckworth, and
J A Kanis, and
C Preston, and
D J Beard, and
T W Smith, and
I Underwood, and
J S Woodhead, and
R G Russell
January 1980,
Advances in experimental medicine and biology,
D L Douglas, and
T Duckworth, and
J A Kanis, and
C Preston, and
D J Beard, and
T W Smith, and
I Underwood, and
J S Woodhead, and
R G Russell
January 1984,
Metabolic bone disease & related research,
D L Douglas, and
T Duckworth, and
J A Kanis, and
C Preston, and
D J Beard, and
T W Smith, and
I Underwood, and
J S Woodhead, and
R G Russell
January 1983,
Metabolic bone disease & related research,
D L Douglas, and
T Duckworth, and
J A Kanis, and
C Preston, and
D J Beard, and
T W Smith, and
I Underwood, and
J S Woodhead, and
R G Russell
February 1985,
Tumori,
D L Douglas, and
T Duckworth, and
J A Kanis, and
C Preston, and
D J Beard, and
T W Smith, and
I Underwood, and
J S Woodhead, and
R G Russell
September 1979,
Lancet (London, England),
D L Douglas, and
T Duckworth, and
J A Kanis, and
C Preston, and
D J Beard, and
T W Smith, and
I Underwood, and
J S Woodhead, and
R G Russell
April 1982,
The Journal of clinical endocrinology and metabolism,
D L Douglas, and
T Duckworth, and
J A Kanis, and
C Preston, and
D J Beard, and
T W Smith, and
I Underwood, and
J S Woodhead, and
R G Russell
April 1982,
La Nouvelle presse medicale,
D L Douglas, and
T Duckworth, and
J A Kanis, and
C Preston, and
D J Beard, and
T W Smith, and
I Underwood, and
J S Woodhead, and
R G Russell
January 1983,
Cancer immunology, immunotherapy : CII,
D L Douglas, and
T Duckworth, and
J A Kanis, and
C Preston, and
D J Beard, and
T W Smith, and
I Underwood, and
J S Woodhead, and
R G Russell
January 1984,
Metabolic bone disease & related research,
D L Douglas, and
T Duckworth, and
J A Kanis, and
C Preston, and
D J Beard, and
T W Smith, and
I Underwood, and
J S Woodhead, and
R G Russell
June 1983,
The New England journal of medicine,
