-transparent.png){kind=logo}
We have isolated a unique, basement membrane proteoglycan from the Engelbreth-Holm-Swarm (EHS) sarcoma. This proteoglycan, estimated to be 0.75 X 10(6) daltons, was found to contain about equal amounts of protein and covalently linked heparan sulfate. Antibody prepared against this proteoglycan reacts with the basement membrane matrix in the tumor and with the basement membranes in skin, kidney, and cornea. These studies indicate that the heparan sulfate proteoglycan is a normal constituent of basement membranes that presumably plays an important role in the organization of basement membrane components and that also may determine the permeability of basement membranes to acidic molecules.
J R Hassell, and
P G Robey, and
H J Barrach, and
J Wilczek, and
S I Rennard, and
G R Martin
March 1988,
The American journal of anatomy,
J R Hassell, and
P G Robey, and
H J Barrach, and
J Wilczek, and
S I Rennard, and
G R Martin
December 1989,
Biological chemistry Hoppe-Seyler,
J R Hassell, and
P G Robey, and
H J Barrach, and
J Wilczek, and
S I Rennard, and
G R Martin
September 1998,
The Journal of biological chemistry,
J R Hassell, and
P G Robey, and
H J Barrach, and
J Wilczek, and
S I Rennard, and
G R Martin
February 1987,
Biochemistry,
J R Hassell, and
P G Robey, and
H J Barrach, and
J Wilczek, and
S I Rennard, and
G R Martin
October 1984,
The Journal of biological chemistry,
J R Hassell, and
P G Robey, and
H J Barrach, and
J Wilczek, and
S I Rennard, and
G R Martin
March 1983,
Laboratory investigation; a journal of technical methods and pathology,
J R Hassell, and
P G Robey, and
H J Barrach, and
J Wilczek, and
S I Rennard, and
G R Martin
April 1985,
The EMBO journal,
J R Hassell, and
P G Robey, and
H J Barrach, and
J Wilczek, and
S I Rennard, and
G R Martin
June 1990,
Biochimica et biophysica acta,
J R Hassell, and
P G Robey, and
H J Barrach, and
J Wilczek, and
S I Rennard, and
G R Martin
July 1984,
FEBS letters,
J R Hassell, and
P G Robey, and
H J Barrach, and
J Wilczek, and
S I Rennard, and
G R Martin
March 1995,
Hypertension (Dallas, Tex. : 1979),
