-transparent.png){kind=logo}
Intrinsic factor (IF) secretion in healthy male subjects was studied in response to pentagastrin stimulation with and without cimetidine, and to impromidine, a histamine H2 receptor agonist. Peak and total IF output were reduced by cimetidine, but the concentration was unchanged and the response was unaffected by administration of the compound for 1 week. The IF secretory response to impromidine was similar to that to pentagastrin. It is suggested that the acid and IF components of the parietal cell secretory response are mediated via different intracellular pathways, that histamine H2 receptors do not fulfill and obligatory role in the secretion of IF and that synthesis of IF is probably not altered by cimetidine.
P C Sharpe, and
J G Mills, and
M A Horton, and
R H Hunt, and
S H Vincent, and
G J Milton-Thompson
January 1978,
Advances in experimental medicine and biology,
P C Sharpe, and
J G Mills, and
M A Horton, and
R H Hunt, and
S H Vincent, and
G J Milton-Thompson
July 1980,
Lancet (London, England),
P C Sharpe, and
J G Mills, and
M A Horton, and
R H Hunt, and
S H Vincent, and
G J Milton-Thompson
January 1973,
Scandinavian journal of gastroenterology,
P C Sharpe, and
J G Mills, and
M A Horton, and
R H Hunt, and
S H Vincent, and
G J Milton-Thompson
January 1981,
Clinical therapeutics,
P C Sharpe, and
J G Mills, and
M A Horton, and
R H Hunt, and
S H Vincent, and
G J Milton-Thompson
November 1970,
Acta medica Scandinavica,
P C Sharpe, and
J G Mills, and
M A Horton, and
R H Hunt, and
S H Vincent, and
G J Milton-Thompson
July 1982,
The Journal of clinical endocrinology and metabolism,
P C Sharpe, and
J G Mills, and
M A Horton, and
R H Hunt, and
S H Vincent, and
G J Milton-Thompson
August 1982,
Lancet (London, England),
P C Sharpe, and
J G Mills, and
M A Horton, and
R H Hunt, and
S H Vincent, and
G J Milton-Thompson
March 1995,
European journal of pharmacology,
P C Sharpe, and
J G Mills, and
M A Horton, and
R H Hunt, and
S H Vincent, and
G J Milton-Thompson
September 2006,
European journal of pharmacology,
P C Sharpe, and
J G Mills, and
M A Horton, and
R H Hunt, and
S H Vincent, and
G J Milton-Thompson
June 1979,
Life sciences,
